Document Detail

Cardiac output and blood flow volume redistribution during acute maternal hypoxia in fetal sheep.
MedLine Citation:
PMID:  20236035     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Acute hypoxia is one of the main causes of poor neonatal outcome. The aim of this study was the investigation of cardiac output (CO) and blood flow redistribution following induction of acute hypoxia in a fetal sheep model. METHOD: We investigated 10 fetal sheep between 108 and 130 days of gestation. Acute hypoxia was induced by reducing the O(2) saturation in the ventilated gas mixture of the maternal sheep to approximately 75%. The CO, placental fraction of CO, Doppler parameters in the ductus venosus (DV), umbilical artery (UA) and vein (UV) were measured. RESULTS: The fetal pO(2) decreased from 47.1 (7.19; 7.35) to 6.89 (6.78; 7.11) mm Hg [P=0.01, median, (95% CI)] during hypoxia. Fetal pH and BE were also significantly reduced. The DV/UV fraction increased from 15.3 (11.5; 19.8) to 51.1 (35.9; 62.1) (P=0.0001). The combined cardiac output [1228.1 (1024.3; 1686.4) vs. 987.8 (834, 1261) mL min(-1)], the placental fraction of the CO [31.5 (26; 42.1) vs. 26.9 (20.6; 29.3)%] and the right to left (R/L) heart ratio [1.76 (1.5; 2.2) vs. 1.3 (1.1; 1.6)] significantly decreased during hypoxia. CONCLUSIONS: Acute hypoxia significantly increases the proportion of the placental blood passing through the DV and reduces the placental fraction of CO and the R/L heart ratio. These findings could be used as early signs of acute fetal hypoxia.
Michael Tchirikov; Miriam Strohner; Alexander Scholz
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of perinatal medicine     Volume:  38     ISSN:  1619-3997     ISO Abbreviation:  J Perinat Med     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-07-06     Completed Date:  2010-09-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0361031     Medline TA:  J Perinat Med     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  387-92     Citation Subset:  IM    
Department of Obstetrics and Gynecology, University Medical Center Mainz, Germany.
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MeSH Terms
Acute Disease
Anoxia / complications*,  physiopathology*,  ultrasonography
Blood Flow Velocity
Blood Volume
Cardiac Output / physiology*
Disease Models, Animal
Fetal Hypoxia / physiopathology,  ultrasonography
Fetus / physiopathology*
Hemodynamics / physiology*
Placenta / blood supply,  ultrasonography
Pregnancy Complications, Cardiovascular / physiopathology*,  ultrasonography

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