| Cardiac norepinephrine kinetics in hypertrophic cardiomyopathy. | |
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MedLine Citation:
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PMID: 2924414 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We examined the uptake and release of norepinephrine in the cardiac circulation and other regional vascular beds in 11 patients with hypertrophic cardiomyopathy (HCM) and in 10 control subjects during simultaneous infusion of tracer-labeled norepinephrine and isoproterenol. Cardiac neuronal uptake of norepinephrine was assessed by comparing regional removal of tracer-labeled norepinephrine with that of tracer-labeled isoproterenol (which is not a substrate for neuronal uptake) and by the relation between production of dihydroxyphenylglycol (DHPG), an exclusively intraneuronal metabolite of norepinephrine, and regional spillover of norepinephrine. Cardiac extraction of norepinephrine averaged 59 +/- 17% in the patients with HCM, significantly less than in the control subjects (79 +/- 13%, p less than 0.05), whereas cardiac extraction of isoproterenol was similar in the two groups (13 +/- 23% versus 13 +/- 14%), indicating that neuronal uptake of norepinephrine was decreased in the patients with HCM. The cardiac arteriovenous difference in norepinephrine was significantly larger in the patients with HCM than in the control subjects (73 +/- 77 versus 13 +/- 50 pg/ml, p less than 0.05), as was the product of the arteriovenous difference in norepinephrine and coronary blood flow (7.3 +/- 7.3 versus 0.8 +/- 3.0 ng/min, p less than 0.05).(ABSTRACT TRUNCATED AT 250 WORDS) |
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Authors:
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J E Brush; G Eisenhofer; M Garty; R Stull; B J Maron; R O Cannon; J A Panza; S E Epstein; D S Goldstein |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Circulation Volume: 79 ISSN: 0009-7322 ISO Abbreviation: Circulation Publication Date: 1989 Apr |
Date Detail:
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Created Date: 1989-05-05 Completed Date: 1989-05-05 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0147763 Medline TA: Circulation Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 836-44 Citation Subset: AIM; IM |
Affiliation:
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Cardiology Branch, National Heart, Lung, and Blood Institute, Bethesda, Maryland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Cardiomyopathy, Hypertrophic / etiology, metabolism* Female Glycols / biosynthesis* Humans Isoproterenol / pharmacokinetics Male Methoxyhydroxyphenylglycol / analogs & derivatives, biosynthesis* Middle Aged Myocardium / metabolism* Neurons / metabolism Norepinephrine / pharmacokinetics* Sympathetic Nervous System / physiopathology Tritium / diagnostic use |
| Chemical | |
Reg. No./Substance:
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0/Glycols; 10028-17-8/Tritium; 3343-19-9/dihydroxyphenylethylene glycol; 51-41-2/Norepinephrine; 534-82-7/Methoxyhydroxyphenylglycol; 7683-59-2/Isoproterenol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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