Document Detail


Cardiac neural crest is dispensable for outflow tract septation in Xenopus.
MedLine Citation:
PMID:  21490068     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In vertebrate embryos, cardiac precursor cells of the primary heart field are specified in the lateral mesoderm. These cells converge at the ventral midline to form the linear heart tube, and give rise to the atria and the left ventricle. The right ventricle and the outflow tract are derived from an adjacent population of precursors known as the second heart field. In addition, the cardiac neural crest contributes cells to the septum of the outflow tract to separate the systemic and the pulmonary circulations. The amphibian heart has a single ventricle and an outflow tract with an incomplete spiral septum; however, it is unknown whether the cardiac neural crest is also involved in outflow tract septation, as in amniotes. Using a combination of tissue transplantations and molecular analyses in Xenopus we show that the amphibian outflow tract is derived from a second heart field equivalent to that described in birds and mammals. However, in contrast to what we see in amniotes, it is the second heart field and not the cardiac neural crest that forms the septum of the amphibian outflow tract. In Xenopus, cardiac neural crest cells remain confined to the aortic sac and arch arteries and never populate the outflow tract cushions. This significant difference suggests that cardiac neural crest cell migration into the cardiac cushions is an amniote-specific characteristic, presumably acquired to increase the mass of the outflow tract septum with the evolutionary need for a fully divided circulation.
Authors:
Young-Hoon Lee; Jean-Pierre Saint-Jeannet
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2011-04-13
Journal Detail:
Title:  Development (Cambridge, England)     Volume:  138     ISSN:  1477-9129     ISO Abbreviation:  Development     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-04-27     Completed Date:  2011-07-01     Revised Date:  2013-06-30    
Medline Journal Info:
Nlm Unique ID:  8701744     Medline TA:  Development     Country:  England    
Other Details:
Languages:  eng     Pagination:  2025-34     Citation Subset:  IM    
Affiliation:
Department of Oral Anatomy, School of Dentistry and Institute of Oral Biosciences, Chonbuk National University, Jeonju 561-756, South Korea.
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MeSH Terms
Descriptor/Qualifier:
Animals
Animals, Genetically Modified
Biological Evolution
Gene Expression Regulation, Developmental
Green Fluorescent Proteins / genetics
Heart / embryology*
Luminescent Proteins / genetics
MyoD Protein / genetics,  metabolism
Neural Crest / cytology,  embryology*
SOX9 Transcription Factor / genetics,  metabolism
SOXE Transcription Factors / genetics,  metabolism
Species Specificity
Xenopus Proteins / genetics,  metabolism
Xenopus laevis / embryology*,  genetics,  metabolism
Grant Support
ID/Acronym/Agency:
R01-DE014212/DE/NIDCR NIH HHS
Chemical
Reg. No./Substance:
0/Luminescent Proteins; 0/MyoD Protein; 0/SOX9 Transcription Factor; 0/SOXE Transcription Factors; 0/Xenopus Proteins; 0/red fluorescent protein; 147336-22-9/Green Fluorescent Proteins
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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