Document Detail


Cardiac neural crest cells provide new insight into septation of the cardiac outflow tract: aortic sac to ventricular septal closure.
MedLine Citation:
PMID:  9576827     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A great deal is unclear about the process of cardiac outflow septation. Much controversy exists regarding the precise details of tissue origins and movements of various components. The contribution of the cardiac neural crest to aorticopulmonary and distal truncal septation has been described; however, the distribution of the neural crest in the proximal outflow and heart is unknown. The present study describes the movement of cardiac neural crest cells from the caudal pharyngeal arches into the outflow tract and base of the heart during the period of outflow septation. Using quail-chick chimeras we found that the cardiac neural crest was distributed to all levels of the outflow tract and into the base of the heart. Septation of the outflow tract lumen occurred by two different processes that involved the cardiac neural crest directly. Cardiac neural crest cells were also distributed to regions of the outflow tract that correlated with sites of remodeling, such as the aortic sac as it was remodeled into the base of the ascending aorta and pulmonary trunk, the distal truncus that was patterned into the two semilunar valves and in the proximal conotruncus where muscularization of the ridges and septum occurred. Additionally, cardiac neural crest cells were found at the site of closure of the ventricular septum, in the wall of the pulmonary infundibulum, and transiently in the wall of the aortic vestibule. Contrary to current thinking, not all of the condensed mesenchyme in the outflow tract during septation was derived from neural crest.
Authors:
K Waldo; S Miyagawa-Tomita; D Kumiski; M L Kirby
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Developmental biology     Volume:  196     ISSN:  0012-1606     ISO Abbreviation:  Dev. Biol.     Publication Date:  1998 Apr 
Date Detail:
Created Date:  1998-05-29     Completed Date:  1998-05-29     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0372762     Medline TA:  Dev Biol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  129-44     Citation Subset:  IM    
Affiliation:
Developmental Biology Program, Medical College of Georgia, Augusta 30912-2640, USA. kwaldo@mail.mcg.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Aorta / embryology*
Cell Movement
Central Nervous System / embryology
Chick Embryo
Heart / embryology
Heart Septum / embryology*
Models, Cardiovascular
Neural Crest / cytology*,  embryology
Quail
Transplantation Chimera
Grant Support
ID/Acronym/Agency:
HD 17063/HD/NICHD NIH HHS; HL36059/HL/NHLBI NIH HHS; HL51533/HL/NHLBI NIH HHS

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