| Cardiac myonecrosis in hypertensive crisis associated with monoamine oxidase inhibitor therapy. | |
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MedLine Citation:
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PMID: 3578343 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A young woman taking tranylcypromine for depression was hospitalized with severe chest pain and hypertension after eating cheese. Electrocardiography initially showed arrhythmias and precordial ST segment depression. Myocardial creatine kinase values were elevated, and echocardiography showed regional ventricular dysfunction, suggestive of focal cardiac myonecrosis. The cardiovascular pathophysiology of tyramine hypertensive crisis and related catecholamine excess states, including pheochromocytoma and clonidine withdrawal, is reviewed. Cardiac myonecrosis is a potential adverse effect of the hypertensive crisis associated with monoamine oxidase inhibitor use. Psychiatric indications for monoamine oxidase inhibitors may be expanding, but clinicians should continue to exercise caution in the use of these agents. |
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Authors:
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L X Liu; A K Rustgi |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: The American journal of medicine Volume: 82 ISSN: 0002-9343 ISO Abbreviation: Am. J. Med. Publication Date: 1987 May |
Date Detail:
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Created Date: 1987-06-19 Completed Date: 1987-06-19 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0267200 Medline TA: Am J Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1060-4 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antidepressive Agents / adverse effects*, therapeutic use Cheese / adverse effects Female Humans Hypertension / chemically induced* Monoamine Oxidase Inhibitors / adverse effects*, therapeutic use Myocardium / pathology* Necrosis Tranylcypromine / adverse effects, therapeutic use Tyramine / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Antidepressive Agents; 0/Monoamine Oxidase Inhibitors; 155-09-9/Tranylcypromine; 51-67-2/Tyramine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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