Document Detail


Cardiac myofibrillar creatine kinase is not influenced by hypothyroidism.
MedLine Citation:
PMID:  2931168     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The cardiac myofibrillar component of the phosphorylcreatine shuttle mechanism enzymatically couples the functionally significant processes of energy utilization (ATPase) with substrate regeneration by creatine kinase (CK). Both components have isoenzyme forms that are transcriptionally regulated. Propylthiouracil-induced (PTU) hypothyroidism reduced rat cardiac contractile protein ATPase activity by shifting isomyosin predominance from the V1 to the V3 form. However, neither CK specific activity or CK isoenzyme composition was altered by PTU treatment. Thus, myofibrillar components of the phosphorylcreatine shuttle, ATPase and CK, are not coordinately regulated under hypothyroid conditions.
Authors:
R T Dowell; A F Martin
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Canadian journal of physiology and pharmacology     Volume:  63     ISSN:  0008-4212     ISO Abbreviation:  Can. J. Physiol. Pharmacol.     Publication Date:  1985 Jun 
Date Detail:
Created Date:  1985-11-04     Completed Date:  1985-11-04     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0372712     Medline TA:  Can J Physiol Pharmacol     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  627-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adenosine Triphosphatases / metabolism
Animals
Creatine Kinase / metabolism*
Female
Hypothyroidism / enzymology*
Isoenzymes
Myocardium / enzymology*
Myofibrils / enzymology*
Myosins / metabolism
Propylthiouracil / pharmacology
Rats
Rats, Inbred Strains
Grant Support
ID/Acronym/Agency:
HL 28456/HL/NHLBI NIH HHS; HL 33677/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Isoenzymes; 51-52-5/Propylthiouracil; EC 2.7.3.2/Creatine Kinase; EC 3.6.1.-/Adenosine Triphosphatases; EC 3.6.4.1/Myosins

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