| Cardiac myocyte nuclear size and ploidy status decrease after mechanical support. | |
| | |
MedLine Citation:
|
PMID: 11425598 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Two patients with end-stage dilated cardiomyopathy of ischemic and idiopathic origin were treated with a left ventricular assist device (LVAD) as a bridge for heart transplantation. Myocardial tissue was collected during LVAD insertion and from the left ventricular apex of the explanted hearts. The myocyte diameter, nuclear area and DNA content of myocyte nuclei were measured by static cytomorphometry in tissue sections and in isolated myocytes with a digital analysis system. The presence of apoptotic nuclei was investigated by the TdT mediated X-dUTP nick end labeling technique (TUNEL). The prolonged use of a LVAD was associated with a reduction in myocyte diameter, indicating that the LVAD may induce a reversion of myocyte hypertrophy, a process described as "reverse remodeling." In addition, unloading of the heart induced a reduction in the size and DNA content of myocyte nuclei. These results suggest that the cardiomyocyte nuclei are in a dynamic state and, as it occurs with cell hypertrophy, nuclear hypertrophy and polyploidization may be a reversible phenomenon. |
| | |
Authors:
|
H G Rivello; P C Meckert; C Vigliano; R Favaloro; R P Laguens |
Related Documents
:
|
23683908 - Oral intercourse or secondary transfer? a bayesian approach of salivary amylase and for... 17918378 - Multiplication of trypanosoma pacifica (euglenozoa: kinetoplastea) in english sole, par... 9024788 - Import of plasmid dna into the nucleus is sequence specific. 3025638 - Extensive mutagenesis of the nuclear location signal of simian virus 40 large-t antigen. 18950138 - Micelles of lipid-oligonucleotide conjugates: implications for membrane anchoring and b... 14729958 - Photo-cross-linking of a purified preinitiation complex reveals central roles for the r... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology Volume: 10 ISSN: 1054-8807 ISO Abbreviation: Cardiovasc. Pathol. Publication Date: 2001 Mar-Apr |
Date Detail:
|
Created Date: 2001-06-26 Completed Date: 2001-08-09 Revised Date: 2006-11-03 |
Medline Journal Info:
|
Nlm Unique ID: 9212060 Medline TA: Cardiovasc Pathol Country: United States |
Other Details:
|
Languages: eng Pagination: 53-7 Citation Subset: IM |
Affiliation:
|
Cátedra de Patología, Universidad Nacional de La Plata, Argentina. hgarciarivello@hotmail.com |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Apoptosis Cardiomyopathy, Dilated / genetics, therapy* Cell Nucleus / pathology* DNA / analysis Heart-Assist Devices* Humans Image Cytometry Image Processing, Computer-Assisted In Situ Nick-End Labeling Male Middle Aged Myocardium / pathology* Ploidies* Ventricular Remodeling / physiology |
| Chemical | |
Reg. No./Substance:
|
9007-49-2/DNA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: A strategy for tumor-selective chemotherapy by enzymatic liberation of seco-duocarmycin SA-derivativ...
Next Document: Diagnosis of human coronary atherosclerosis by morphology-based Raman spectroscopy.