Document Detail


Cardiac morbidity and mortality due to Chagas' disease: prospective electrocardiographic study of a Brazilian community.
MedLine Citation:
PMID:  3552307     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The evolution of Chagas' cardiomyopathy is poorly understood. We therefore examined the development of cardiac lesions in a rural Brazilian community for a period of 7 years. Initially, 42% of 1017 residents were seropositive for infection with Trypanosoma cruzi. Age-specific infection rates indicated that most had become infected before the age of 20 years. On follow-up, it appeared that those persons who developed cardiac lesions did so soon after infection, since the incidence of right bundle branch block and other ventricular conduction defects (VCDs) was also highest before age 20 years. The progressive nature of these lesions was demonstrated by frequent development of additional electrocardiographic abnormalities and high mortality among infected adults with VCDs. In contrast, mortality was low and approximately the same for seropositive and seronegative adults under 60 years who had normal electrocardiograms. Electrocardiography during the early asymptomatic stage of infection was able to distinguish persons with potentially lethal cardiac lesions from those with a benign prognosis.
Authors:
J H Maguire; R Hoff; I Sherlock; A C Guimarães; A C Sleigh; N B Ramos; K E Mott; T H Weller
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Circulation     Volume:  75     ISSN:  0009-7322     ISO Abbreviation:  Circulation     Publication Date:  1987 Jun 
Date Detail:
Created Date:  1987-06-24     Completed Date:  1987-06-24     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0147763     Medline TA:  Circulation     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1140-5     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Age Factors
Antibodies / analysis
Brazil
Chagas Cardiomyopathy / diagnosis,  epidemiology*,  mortality
Electrocardiography
Follow-Up Studies
Humans
Prospective Studies
Rural Population
Trypanosoma cruzi / immunology
Grant Support
ID/Acronym/Agency:
AI 16305-05/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Antibodies

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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