Document Detail


Cardiac metabolsim: its contributions to alcoholic heart disease and myocardial failure.
MedLine Citation:
PMID:  152168     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Changes in cardiac metabolism in myocardial failure and after alcohol ingestion are discussed. The main effect of alcohol ingestion is loss of cardiac contractility. Since heart muscle does not contain alcohol dehydrogenase, its toxicity is probably the result of a direct toxic effect of ethanol and acetaldehyde on the myocardial cell, possibly involving various membrane systems. Alcohol inhibits mitochondrial respiration and the activity of enzymes in the tricarboxylic acid cycle, and its interferes with both mitochondrial calcium uptake and binding. Ethanol profoundly affects myocardial lipid metabolism. Acetaldehyde diminishes myocardial protein synthesis and inhibits Ca++-activated myofibrillar ATPase. In myocardial failure, a series of possibilities may be responsible for the loss of contractility. Excitation-contraction coupling could be disturbed at the level of the sarcolemma, at the sarcoplasmic reticulum, at the mitochondria, and between calcium and the regulatory proteins. Deficiencies in Ca++ delivery systems of excitation-contraction coupling on the myosin ATPase activity could be responsible for the dimunition in cardiac contractility. Mitochondrial function may also be involved, since mitochondria from failing human hearts are defective with respect to respiratory control and calcium accumulation. Under certain conditions, the relationship of mitochondria to calcium sequestration is very important in influencing contractility. The involvement of contractile and regulatory proteins in myocardial failure cannot be excluded.
Authors:
R J Bing
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Circulation     Volume:  58     ISSN:  0009-7322     ISO Abbreviation:  Circulation     Publication Date:  1978 Dec 
Date Detail:
Created Date:  1979-01-26     Completed Date:  1979-01-26     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0147763     Medline TA:  Circulation     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  965-70     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Acetaldehyde / toxicity
Alcoholic Intoxication / enzymology,  metabolism
Animals
Calcium / metabolism
Calcium-Transporting ATPases / metabolism
Cardiomyopathy, Alcoholic / enzymology,  metabolism*
Heart / drug effects*
Heart Failure / enzymology,  etiology,  metabolism*
Humans
Lipid Metabolism
Mitochondria, Heart / drug effects,  enzymology,  metabolism
Muscle Proteins / biosynthesis
Myocardial Contraction / drug effects
Myocardium / enzymology,  metabolism*
Myofibrils / enzymology
Sarcolemma / drug effects,  metabolism
Sarcoplasmic Reticulum / drug effects,  metabolism
Chemical
Reg. No./Substance:
0/Muscle Proteins; 7440-70-2/Calcium; 75-07-0/Acetaldehyde; EC 3.6.1.8/Calcium-Transporting ATPases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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