Document Detail


Cardiac and metabolic effects of anabolic-androgenic steroid abuse on lipids, blood pressure, left ventricular dimensions, and rhythm.
MedLine Citation:
PMID:  20816133     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Recent surveys and reports suggest that many athletes and bodybuilders abuse anabolic-androgenic steroids (AAS). However, scientific data on the cardiac and metabolic complications of AAS abuse are divergent and often conflicting. A total of 49 studies describing 1,467 athletes were reviewed to investigate the cardiovascular effects of the abuse of AAS. Although studies were typically small and retrospective, some associated AAS abuse with unfavorable effects. Otherwise healthy young athletes abusing AAS may show elevated levels of low-density lipoprotein and low levels of high-density lipoprotein. Although data are conflicting, AAS have also been linked with elevated systolic and diastolic blood pressure and with left ventricular hypertrophy that may persist after AAS cessation. Finally, in small case studies, AAS abuse has been linked with acute myocardial infarction and fatal ventricular arrhythmias. In conclusion, recognition of these adverse effects may improve the education of athletes and increase vigilance when evaluating young athletes with cardiovascular abnormalities.
Authors:
Suraj Achar; Armand Rostamian; Sanjiv M Narayan
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The American journal of cardiology     Volume:  106     ISSN:  1879-1913     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-09-06     Completed Date:  2010-09-28     Revised Date:  2014-07-28    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  893-901     Citation Subset:  AIM; IM    
Copyright Information:
Copyright 2010 Elsevier Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Anabolic Agents / adverse effects*,  pharmacology
Androgens / adverse effects*,  pharmacology
Arrhythmias, Cardiac / chemically induced
Athletes
Blood Pressure / drug effects
Doping in Sports*
Evidence-Based Medicine
Heart / drug effects
Heart Rate / drug effects*
Heart Ventricles / drug effects
Humans
Hypertrophy, Left Ventricular / chemically induced*,  metabolism*
Lipids / biosynthesis*
Lipoproteins, HDL / drug effects
Lipoproteins, LDL / drug effects
Myocardial Infarction / chemically induced
Grant Support
ID/Acronym/Agency:
K24 HL103800/HL/NHLBI NIH HHS; K24 HL103800-02/HL/NHLBI NIH HHS; R01 HL083359-04/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Anabolic Agents; 0/Androgens; 0/Lipids; 0/Lipoproteins, HDL; 0/Lipoproteins, LDL

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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