| Cardiac and metabolic effects of anabolic-androgenic steroid abuse on lipids, blood pressure, left ventricular dimensions, and rhythm. | |
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MedLine Citation:
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PMID: 20816133 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Recent surveys and reports suggest that many athletes and bodybuilders abuse anabolic-androgenic steroids (AAS). However, scientific data on the cardiac and metabolic complications of AAS abuse are divergent and often conflicting. A total of 49 studies describing 1,467 athletes were reviewed to investigate the cardiovascular effects of the abuse of AAS. Although studies were typically small and retrospective, some associated AAS abuse with unfavorable effects. Otherwise healthy young athletes abusing AAS may show elevated levels of low-density lipoprotein and low levels of high-density lipoprotein. Although data are conflicting, AAS have also been linked with elevated systolic and diastolic blood pressure and with left ventricular hypertrophy that may persist after AAS cessation. Finally, in small case studies, AAS abuse has been linked with acute myocardial infarction and fatal ventricular arrhythmias. In conclusion, recognition of these adverse effects may improve the education of athletes and increase vigilance when evaluating young athletes with cardiovascular abnormalities. |
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Authors:
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Suraj Achar; Armand Rostamian; Sanjiv M Narayan |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: The American journal of cardiology Volume: 106 ISSN: 1879-1913 ISO Abbreviation: Am. J. Cardiol. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-09-06 Completed Date: 2010-09-28 Revised Date: 2011-06-14 |
Medline Journal Info:
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Nlm Unique ID: 0207277 Medline TA: Am J Cardiol Country: United States |
Other Details:
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Languages: eng Pagination: 893-901 Citation Subset: AIM; IM |
Copyright Information:
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Copyright 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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University of California, San Diego, San Diego, California, USA. sachar@ucsd.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anabolic Agents
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adverse effects*,
pharmacology Androgens / adverse effects*, pharmacology Arrhythmias, Cardiac / chemically induced Athletes Blood Pressure / drug effects Doping in Sports* Evidence-Based Medicine Heart / drug effects Heart Rate / drug effects* Heart Ventricles / drug effects Humans Hypertrophy, Left Ventricular / chemically induced*, metabolism* Lipids / biosynthesis* Lipoproteins, HDL / drug effects Lipoproteins, LDL / drug effects Myocardial Infarction / chemically induced |
| Grant Support | |
ID/Acronym/Agency:
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K24 HL103800-02/HL/NHLBI NIH HHS; R01 HL083359-04/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Anabolic Agents; 0/Androgens; 0/Lipids; 0/Lipoproteins, HDL; 0/Lipoproteins, LDL |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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