Document Detail

Cardiac memory induced by QRS widening due to propafenone toxicity.
MedLine Citation:
PMID:  17725763     Owner:  NLM     Status:  MEDLINE    
Propafenone toxicity can cause significant QRS widening and markedly abnormal ventricular activation pattern. Aberrant ventricular activation upon its resolution is known to produce persistent T-wave changes known as "cardiac memory" (CM). A 74-year-old woman presented with a severely abnormal electrocardiogram consistent with propafenone toxicity. As her QRS complex narrowed, T-wave inversions developed with the T-wave axis and resolution kinetics consistent with CM. Abnormal ventricular activation due to propafenone toxicity can result in CM development.
John V Wylie; Peter Zimetbaum; Mark E Josephson; Alexei Shvilkin
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Pacing and clinical electrophysiology : PACE     Volume:  30     ISSN:  0147-8389     ISO Abbreviation:  Pacing Clin Electrophysiol     Publication Date:  2007 Sep 
Date Detail:
Created Date:  2007-08-29     Completed Date:  2007-12-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7803944     Medline TA:  Pacing Clin Electrophysiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1161-4     Citation Subset:  IM    
Harvard-Thorndike Electrophysiology Institute,Harvard Medical School, Boston, Massachusetts, USA.
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MeSH Terms
Anti-Arrhythmia Agents / therapeutic use
Atrial Fibrillation / chemically induced*,  diagnosis,  drug therapy*,  prevention & control
Propafenone / adverse effects*
Ventricular Fibrillation / chemically induced*,  diagnosis*,  prevention & control
Reg. No./Substance:
0/Anti-Arrhythmia Agents; 54063-53-5/Propafenone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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