| Cardiac membrane fatty acid composition modulates myocardial oxygen consumption and postischemic recovery of contractile function. | |
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MedLine Citation:
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PMID: 12010914 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Regular fish consumption is associated with low cardiovascular disease morbidity and mortality. Fish oils modify cardiac membrane phospholipid fatty acid composition with potent antiarrhythmic effects. We tested the effects of dietary fish oil on ventricular hemodynamics and myocardial oxygen consumption (MVO2). METHODS AND RESULTS: Male Wistar rats were fed for 16 weeks on a reference diet rich in n-6 polyunsaturated fatty acids (PUFA), a diet rich in saturated animal fat (SAT), or a diet rich in n-3 PUFA from fish oil. Isolated working hearts were perfused with porcine erythrocytes (40% hematocrit) at 75 mm Hg afterload with variable preload (5 to 20 mm Hg) or with low coronary flow ischemia with maintained afterload, preload, and heart rate, then reperfused. MVO2 was low and coronary perfusion reserve high in n-3 PUFA hearts, and cardiac output increased with workload. The n-3 PUFA reduced ischemic markers-acidosis, K+, lactate, and creatine kinase-and increased contractile recovery during reperfusion. SAT hearts had high MVO2, low coronary perfusion reserve, and poor contractile function and recovery. Dietary differences in MVO2 were abolished by KCl arrest (basal metabolism) or ruthenium red (3.4 micromol/L) but not by ryanodine (1 nmol/L). Fish oil or ryanodine, but not ruthenium red, prevented ventricular fibrillation in reperfusion. CONCLUSIONS: Dietary fish oil directly influenced heart function and improved cardiac responses to ischemia and reperfusion. The n-3 PUFA reduced oxygen consumption at any given work output and increased postischemic recovery. Thus, direct effects on myocardial function may contribute to the altered cardiovascular disease profile associated with fish consumption. |
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Authors:
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Salvatore Pepe; Peter L McLennan |
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Publication Detail:
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Type: In Vitro; Journal Article |
Journal Detail:
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Title: Circulation Volume: 105 ISSN: 1524-4539 ISO Abbreviation: Circulation Publication Date: 2002 May |
Date Detail:
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Created Date: 2002-05-15 Completed Date: 2002-05-24 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0147763 Medline TA: Circulation Country: United States |
Other Details:
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Languages: eng Pagination: 2303-8 Citation Subset: AIM; IM |
Affiliation:
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Cardiac Surgical Research Unit, Alfred Hospital and Baker Medical Research Institute, Monash University Faculty of Medicine, Melbourne, Australia. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Flow Velocity / drug effects, physiology Calcium / metabolism Cardiac Output / drug effects, physiology Cell Membrane / metabolism* Coronary Circulation / drug effects, physiology Diet Dietary Fats, Unsaturated / pharmacology* Fatty Acids / metabolism*, pharmacology Fatty Acids, Omega-3 / pharmacology Fatty Acids, Omega-6 Fatty Acids, Unsaturated / pharmacology Fish Oils / pharmacology Hemodynamics / drug effects, physiology Intracellular Fluid / metabolism Male Myocardial Ischemia / metabolism Myocardial Reperfusion Myocardium / chemistry, metabolism* Oxygen Consumption / drug effects* Rats Rats, Wistar Ruthenium Red / pharmacology Ryanodine / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Dietary Fats, Unsaturated; 0/Fatty Acids; 0/Fatty Acids, Omega-3; 0/Fatty Acids, Omega-6; 0/Fatty Acids, Unsaturated; 0/Fish Oils; 11103-72-3/Ruthenium Red; 15662-33-6/Ryanodine; 7440-70-2/Calcium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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