Document Detail

Cardiac markers in different degrees of chronic kidney disease: influence of inflammation and former heart disease.
MedLine Citation:
PMID:  21807382     Owner:  NLM     Status:  Publisher    
BACKGROUND AND OBJECTIVE: Troponin T (TnT), brain natriuretic peptide (BNP) and its precursor (NT-proBNP) are useful markers of acute coronary events and heart failure. The aim of this study was to analyze the influence of chronic renal failure, inflammation and heart disease in these biomarkers. PATIENTS AND METHODS: In 266 patients with different stages of chronic renal diseases, the following parameters were measured: cardiac markers (TnT, BNP and NT-proBNP), renal function, inflammatory markers (hsCRP, fibrinogen, albumin, uric acid and white blood cells). We recorded the cardiovascular history. Ventricular dysfunction and left ventricular hypertrophy were assessed by echocardiography. RESULTS: A significant correlation between cardiac markers and inflammatory parameters such as fibrinogen, hsCRP and albumin was found. Age (OR 1.05, P = .021), serum albumin (OR: 0.06, P=.006), ischemic heart disease (OR: 8.17, P=.0092) and renal failure (OR: 1.67, P=.05) were predictors of higher BNP levels. Age (OR 1.05, P=.0097), serum albumin (OR: 0.12, P=.001), ischemic heart disease (OR: 3.43, P=.034), renal failure (OR: 1, 65, P=.036) and heart failure (OR: 4.33, P=.0312) were predictors of elevated NT-proBNP. Previous ischemic heart disease alone increased TnT levels (OR: 6.51, P=.0012). CONCLUSIONS: Age, previous cardiac disease and inflammation increase cardiac marker levels in patients with different stages of renal disease, but the degree of renal failure is an important factor influencing NT-proBNP levels. However, ischemic heart disease alone increases the levels of TnT.
Borja Quiroga; Marian Goicoechea; Soledad García de Vinuesa; Eduardo Verde; Ursula Verdalles; Claudia Yuste; Javier Reque; José Luño
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-7-30
Journal Detail:
Title:  Medicina clinica     Volume:  -     ISSN:  0025-7753     ISO Abbreviation:  -     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-8-2     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376377     Medline TA:  Med Clin (Barc)     Country:  -    
Other Details:
Languages:  SPA     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Elsevier España, S.L. All rights reserved.
Servicio de Nefrología, Hospital General Universitario Gregorio Marañón, Madrid, España.
Vernacular Title:
Marcadores cardiacos en diferentes grados de enfermedad renal crónica: influencia de la inflamación y de afectación cardiaca previa.
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