Document Detail


Cardiac magnetic resonance appearance of myocarditis caused by high dose IL-2: similarities to community-acquired myocarditis.
MedLine Citation:
PMID:  16669178     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The purpose of this study was to describe and compare the cardiac magnetic resonance (CMR) characteristics of myocarditis caused by high dose interleukin-2 (7 patients) with community-acquired myocarditis (14 patients). A total of 21 patients with suspected myocarditis and elevated cardiac enzymes underwent cine CMR followed by delayed enhancement. The mean ejection fraction was mildly decreased in both groups. The location, pattern, and extent of DE were similar in both groups of patients. The CMR similarities between these two populations suggest that cytokine-mediated cytotoxicity may play an important role in community-acquired myocarditis.
Authors:
W Patricia Ingkanisorn; D Ian Paterson; Katherine R Calvo; Douglas R Rosing; Douglas J Schwartzentruber; Anthon R Fuisz; Andrew E Arai
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Intramural    
Journal Detail:
Title:  Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance     Volume:  8     ISSN:  1097-6647     ISO Abbreviation:  J Cardiovasc Magn Reson     Publication Date:  2006  
Date Detail:
Created Date:  2006-05-03     Completed Date:  2006-09-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9815616     Medline TA:  J Cardiovasc Magn Reson     Country:  United States    
Other Details:
Languages:  eng     Pagination:  353-60     Citation Subset:  IM    
Affiliation:
National Heart, Lung, and Blood Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892-1061, USA.
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MeSH Terms
Descriptor/Qualifier:
Aged
Antineoplastic Agents / administration & dosage,  adverse effects*
Female
Humans
Interleukin-2 / administration & dosage,  adverse effects*
Magnetic Resonance Imaging, Cine / methods*
Male
Melanoma / drug therapy
Middle Aged
Myocarditis / chemically induced*
Retrospective Studies
Statistics, Nonparametric
Chemical
Reg. No./Substance:
0/Antineoplastic Agents; 0/Interleukin-2

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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