Document Detail

Cardiac lymph flow and composition in acute myocardial ischemia in dogs.
MedLine Citation:
PMID:  238406     Owner:  NLM     Status:  MEDLINE    
Cardiac lymph was obtained from 12 normal dogs (group 1) for two consecutive 2-h control periods and from 7 dogs (group 2) for 2 h before and 2 h after occlusion of the circumflex branch of the left coronary artery. Lymph composition was studied with reference to pH, red blood cell (RBC) concentration, total protein content, potassium and sodium ion concentrations, and creatine phosphokinase (CPK) and acid phosphatase enzyme activities. No significant difference was noted in any variable between the two groups during the firts 2-h period. In group 1, no significant changes occurred in any variable as a result of the passage of time alone. In group 2, 2 h of myocardial ischemia produced increases of 53.3 plus or minus 5.1% in lymph flow, 67 plus or minus 5% in protein content, and 418 plus or minus 27% in the RBC concentration, suggesting increased blood capillary permeability. Lactate rose 120.5 plus or minus 27%, potassium concentration increased 16.9 plus or minus 2.4%, acid phosphatase increased 30 plus or minus 3%, and CPK rose 61.6 pluse or minus 10.9%, suggesting ischemic injury of myocardial cells. These changes in lymph were statistically significant (P LESS THAN 0.05) and reflect both capillary and myocardial cell abnormalities.
M Feola; G Glick
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  229     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1975 Jul 
Date Detail:
Created Date:  1975-10-11     Completed Date:  1975-10-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  44-8     Citation Subset:  IM    
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MeSH Terms
Capillary Permeability
Cell Membrane Permeability
Central Venous Pressure
Creatine Kinase / metabolism
Heart Rate
Hydrogen-Ion Concentration
Lactates / analysis
Lymph / analysis,  cytology,  enzymology
Lymphatic System / physiopathology*
Myocardial Infarction / physiopathology*
Phosphoric Monoester Hydrolases / metabolism
Potassium / analysis
Proteins / analysis
Sodium / analysis
Reg. No./Substance:
0/Lactates; 0/Proteins; 7440-09-7/Potassium; 7440-23-5/Sodium; EC Kinase; EC 3.1.3.-/Phosphoric Monoester Hydrolases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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