| Cardiac lymph flow and composition in acute myocardial ischemia in dogs. | |
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MedLine Citation:
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PMID: 238406 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cardiac lymph was obtained from 12 normal dogs (group 1) for two consecutive 2-h control periods and from 7 dogs (group 2) for 2 h before and 2 h after occlusion of the circumflex branch of the left coronary artery. Lymph composition was studied with reference to pH, red blood cell (RBC) concentration, total protein content, potassium and sodium ion concentrations, and creatine phosphokinase (CPK) and acid phosphatase enzyme activities. No significant difference was noted in any variable between the two groups during the firts 2-h period. In group 1, no significant changes occurred in any variable as a result of the passage of time alone. In group 2, 2 h of myocardial ischemia produced increases of 53.3 plus or minus 5.1% in lymph flow, 67 plus or minus 5% in protein content, and 418 plus or minus 27% in the RBC concentration, suggesting increased blood capillary permeability. Lactate rose 120.5 plus or minus 27%, potassium concentration increased 16.9 plus or minus 2.4%, acid phosphatase increased 30 plus or minus 3%, and CPK rose 61.6 pluse or minus 10.9%, suggesting ischemic injury of myocardial cells. These changes in lymph were statistically significant (P LESS THAN 0.05) and reflect both capillary and myocardial cell abnormalities. |
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Authors:
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M Feola; G Glick |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The American journal of physiology Volume: 229 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1975 Jul |
Date Detail:
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Created Date: 1975-10-11 Completed Date: 1975-10-11 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 44-8 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Capillary Permeability Cell Membrane Permeability Central Venous Pressure Creatine Kinase / metabolism Dogs Erythrocytes Heart Rate Hydrogen-Ion Concentration Lactates / analysis Lymph / analysis, cytology, enzymology Lymphatic System / physiopathology* Myocardial Infarction / physiopathology* Phosphoric Monoester Hydrolases / metabolism Potassium / analysis Proteins / analysis Sodium / analysis |
| Chemical | |
Reg. No./Substance:
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0/Lactates; 0/Proteins; 7440-09-7/Potassium; 7440-23-5/Sodium; EC 2.7.3.2/Creatine Kinase; EC 3.1.3.-/Phosphoric Monoester Hydrolases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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