| Cardiac ischemia model for +Gz using miniature swine and baboons. | |
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MedLine Citation:
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PMID: 18457294 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Military aircrew with minimal coronary artery disease (MCAD) may be restricted from flying high-performance aircraft due to possible ischemia during high +Gz. An animal model is presented to provide ischemia data for a more informed decision. METHODS: There were 18 swine that were placed on a high cholesterol/high fat diet for up to 57 wk. Five control swine were maintained on a standard swine diet. Also, nine male baboons had a constrictor placed around the left anterior descending coronary artery. Two baboons were sham-operated controls. The unanesthetized swine and baboons were infused with Tc-99m at the end of +Gz exposure and scanned for myocardial perfusion. RESULTS: Five swine died unexpectedly before +Gz exposure with moderate-to-severe CAD. Dysrhythmias during +Gz were seen equally in both the control and experimental swine and in the baboons before and after stenosis, with or without propranolol. During +Gz, ECG ST-T wave changes suggesting ischemia were observed in the cholesterol swine but not the control swine, and in the baboons before and after stenosis, with or without propranolol. There was a positive relationship between a normal/abnormal ECG and a normal/abnormal myocardial perfusion scan in the swine and a weak relationship in the baboon before stenosis, but somewhat better after stenosis. Coronary histopathology showed normal vessels from the control swine and stenoses ranging from 0-95% from the cholesterol swine. Baboon stenosis averaged 37.6 +/- 15.0%. CONCLUSIONS: In the swine and the baboon extended high levels of +Gz, were associated with evidence of myocardial ischemia. |
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Authors:
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John W Burns; William B Kruyer; Paul V Celio; Joseph Deering; Thomas H Loecker; Londe A Richardson; John W Fanton; Harold Davis; Edward J Dick |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Aviation, space, and environmental medicine Volume: 79 ISSN: 0095-6562 ISO Abbreviation: Aviat Space Environ Med Publication Date: 2008 Apr |
Date Detail:
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Created Date: 2008-05-06 Completed Date: 2008-07-17 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7501714 Medline TA: Aviat Space Environ Med Country: United States |
Other Details:
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Languages: eng Pagination: 374-83 Citation Subset: IM; S |
Affiliation:
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Biosciences and Protection Division, Air Force Research Laboratory Brooks City-Base, TX, USA. john.burns@amedd.army.mil |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aerospace Medicine Animals Coronary Angiography Coronary Stenosis / pathology Coronary Vessels / pathology Electrocardiography Female Heart Rate Hypergravity* Lipids / blood Male Myocardial Ischemia / pathology, physiopathology*, radiography Papio cynocephalus Swine Swine, Miniature Tomography, Emission-Computed, Single-Photon |
| Chemical | |
Reg. No./Substance:
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0/Lipids |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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