Document Detail

Cardiac ischemia model for +Gz using miniature swine and baboons.
MedLine Citation:
PMID:  18457294     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Military aircrew with minimal coronary artery disease (MCAD) may be restricted from flying high-performance aircraft due to possible ischemia during high +Gz. An animal model is presented to provide ischemia data for a more informed decision. METHODS: There were 18 swine that were placed on a high cholesterol/high fat diet for up to 57 wk. Five control swine were maintained on a standard swine diet. Also, nine male baboons had a constrictor placed around the left anterior descending coronary artery. Two baboons were sham-operated controls. The unanesthetized swine and baboons were infused with Tc-99m at the end of +Gz exposure and scanned for myocardial perfusion. RESULTS: Five swine died unexpectedly before +Gz exposure with moderate-to-severe CAD. Dysrhythmias during +Gz were seen equally in both the control and experimental swine and in the baboons before and after stenosis, with or without propranolol. During +Gz, ECG ST-T wave changes suggesting ischemia were observed in the cholesterol swine but not the control swine, and in the baboons before and after stenosis, with or without propranolol. There was a positive relationship between a normal/abnormal ECG and a normal/abnormal myocardial perfusion scan in the swine and a weak relationship in the baboon before stenosis, but somewhat better after stenosis. Coronary histopathology showed normal vessels from the control swine and stenoses ranging from 0-95% from the cholesterol swine. Baboon stenosis averaged 37.6 +/- 15.0%. CONCLUSIONS: In the swine and the baboon extended high levels of +Gz, were associated with evidence of myocardial ischemia.
John W Burns; William B Kruyer; Paul V Celio; Joseph Deering; Thomas H Loecker; Londe A Richardson; John W Fanton; Harold Davis; Edward J Dick
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Aviation, space, and environmental medicine     Volume:  79     ISSN:  0095-6562     ISO Abbreviation:  Aviat Space Environ Med     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-05-06     Completed Date:  2008-07-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7501714     Medline TA:  Aviat Space Environ Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  374-83     Citation Subset:  IM; S    
Biosciences and Protection Division, Air Force Research Laboratory Brooks City-Base, TX, USA.
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MeSH Terms
Aerospace Medicine
Coronary Angiography
Coronary Stenosis / pathology
Coronary Vessels / pathology
Heart Rate
Lipids / blood
Myocardial Ischemia / pathology,  physiopathology*,  radiography
Papio cynocephalus
Swine, Miniature
Tomography, Emission-Computed, Single-Photon
Reg. No./Substance:

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