| Cardiac iron overload in transfusion-dependent patients with myelodysplastic syndromes. | |
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MedLine Citation:
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PMID: 21689086 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Transfusion-dependent myelodysplastic (MDS) patients are prone to iron overload. We evaluated 43 transfused MDS patients with T2* magnetic resonance imaging scans. 81% had liver and 16·8% cardiac iron overload. Liver R2* (1000/T2*), but not cardiac R2*, was correlated with number of units transfused (r = 0·72, P < 0·0001) and ferritin (r = 0·53, P < 0·0001). The area under the curve of a time-ferritin plot was found to be much greater in patients with cardiac iron loading (median 53·7 × 10(5) Megaunits vs. 12·2 × 10(5) Megaunits, P = 0·002). HFE, HFE2, HAMP or SLC40A1 genotypes were not predictors of iron overload in these patients. |
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Authors:
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Noémi B A Roy; Saul Myerson; Anna H Schuh; Patricia Bignell; Roger Patel; Jim S Wainscoat; Simon McGowan; Emanuele Marchi; Wale Atoyebi; Tim Littlewood; Joseph Chacko; Paresh Vyas; Sally B Killick |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-6-21 |
Journal Detail:
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Title: British journal of haematology Volume: - ISSN: 1365-2141 ISO Abbreviation: - Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-6-21 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372544 Medline TA: Br J Haematol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2011 Blackwell Publishing Ltd. |
Affiliation:
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Molecular Haematology Unit, Weatherall Institute of Molecular Medicine Department of Cardiology, Oxford Radcliffe Hospitals Haemato-Molecular Diagnostic Service, Oxford Radcliffe Hospitals, Oxford Radiology Department, Royal Bournemouth Hospital, Bournemouth Department of Haematology, Oxford Radcliffe Hospitals Computational Biology Research Group, Weatherall Institute of Molecular Medicine, Oxford Department of Haematology, Royal Bournemouth Hospital, Bournemouth, UK. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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