| Cardiac involvement in systemic sclerosis assessed by tissue-doppler echocardiography during routine care: A controlled study of 100 consecutive patients. | |
| | |
MedLine Citation:
|
PMID: 18512815 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: To assess the prevalence of primary cardiac complications in a large population of patients with systemic sclerosis (SSc), using recently developed echocardiographic techniques. METHODS: We prospectively studied 100 consecutive patients (mean +/- SD age 54 +/- 14 years; 86 women) presenting with SSc without pulmonary arterial hypertension or clinical manifestations of heart failure. All patients underwent standard echocardiography, along with measurements of longitudinal velocities by tissue Doppler imaging (TDI) to assess left ventricular (LV) and right ventricular (RV) contractility and LV diastolic function. Results were compared with those in 26 age- and sex-matched healthy controls. RESULTS: Patients with SSc had a wider mean left atrial diameter and impaired relaxation compared with the controls. A trend was observed toward a smaller LV ejection fraction (EF) in the patients (mean +/- SD 64.9 +/- 0.6%) than in the controls (67.2 +/- 0.7%), as well as higher pulmonary artery pressure (mean +/- SD 33.3 +/- 0.6 mm Hg versus 30.8 +/- 1.0 mm Hg). LVEF was <55% in 7 patients versus none of the controls. Peak systolic mitral annular velocity as measured by TDI was <7.5 cm/second in 14 patients versus none of the controls (P = 0.040). Mitral annulus early diastolic velocity was <10 cm/second in 30 patients versus 2 of the controls (P = 0.022). Fifteen patients and none of the controls had reduced peak systolic tricuspid annular velocity (P = 0.039). The TDI results correlated with each other, but not with lung abnormalities or other disease characteristics. CONCLUSION: Depression of LV and RV systolic and LV diastolic function is common in patients with SSc and is due to primary myocardial involvement. Considering the major contributions of TDI, the addition of this simple technique to standard measurements may improve the detection of heart involvement in patients with SSc. |
| | |
Authors:
|
Christophe Meune; Jérôme Avouac; Karim Wahbi; Laure Cabanes; Julien Wipff; Luc Mouthon; Loïc Guillevin; André Kahan; Yannick Allanore |
Related Documents
:
|
15297785 - Changes of the cardiac architectures and functions for chronic hemodialysis patients wi... 19435825 - Impact of resistance to thyroid hormone on the cardiovascular system in adults. 501925 - Echocardiographic evaluation of right ventricular anterior wall motion in the wolff-par... 16319835 - Structural and functional affection of the heart in protein energy malnutrition patient... 22305845 - Effect of qrs morphology on clinical event reduction with cardiac resynchronization the... 655905 - Normal pressure hydrocephalus. recognition and relationship to neurological abnormaliti... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Arthritis and rheumatism Volume: 58 ISSN: 0004-3591 ISO Abbreviation: Arthritis Rheum. Publication Date: 2008 Jun |
Date Detail:
|
Created Date: 2008-06-19 Completed Date: 2008-07-24 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0370605 Medline TA: Arthritis Rheum Country: United States |
Other Details:
|
Languages: eng Pagination: 1803-9 Citation Subset: AIM; IM |
Affiliation:
|
Hôpital Cochin, Université Paris Descartes, Assistance Publique Hôpitaux de Paris, Paris, France. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Case-Control Studies Echocardiography, Doppler Female Heart Ventricles / pathology, ultrasonography Humans Male Middle Aged Myocardial Contraction Prospective Studies Scleroderma, Systemic / complications* Stroke Volume Ventricular Dysfunction, Left / etiology*, pathology, ultrasonography Ventricular Dysfunction, Right / etiology*, ultrasonography |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Systemic lupus international collaborating clinics renal activity/response exercise: comparison of a...
Next Document: A multicenter, randomized, double-blind, placebo-controlled trial of oral type I collagen treatment ...