Document Detail


Cardiac involvement in systemic lupus erythematosus.
MedLine Citation:
PMID:  16218467     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Pericarditis is the most common cardiac abnormality in systemic lupus erythematosus (SLE) patients, but lesions of the valves, myocardium and coronary vessels may all occur. In the past, cardiac manifestations were severe and life threatening, often leading to death. Therefore, they were frequently found in post-mortem examinations. Nowadays cardiac manifestations are often mild and asymptomatic. However, they can be frequently recognized by echocardiography and other noninvasive tests. Echocardiography is a sensitive and specific technique in detecting cardiac abnormalities, particularly mild pericarditis, valvular lesions and myocardial dysfunction. Therefore, echocardiography should be performed periodically in SLE patients. Vascular occlusion, including coronary arteries, may develop due to vasculitis, premature atherosclerosis or antiphospholipid antibodies associated with SLE. Premature atherosclerosis is the most frequent cause of coronary artery disease (CAD) in SLE patients. Efforts should be made to control traditional risk factors as well as all other factors which could contribute to atherosclerotic plaque development.
Authors:
A Doria; L Iaccarino; P Sarzi-Puttini; F Atzeni; M Turriel; M Petri
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Lupus     Volume:  14     ISSN:  0961-2033     ISO Abbreviation:  Lupus     Publication Date:  2005  
Date Detail:
Created Date:  2005-10-12     Completed Date:  2005-12-21     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9204265     Medline TA:  Lupus     Country:  England    
Other Details:
Languages:  eng     Pagination:  683-6     Citation Subset:  IM    
Affiliation:
Division of Rheumatology, University of Padua, Padua, Italy. adoria@unipd.it
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MeSH Terms
Descriptor/Qualifier:
Cardiovascular Diseases / etiology*,  immunology,  pathology,  physiopathology
Coronary Vessels / pathology,  physiopathology
Echocardiography
Heart / physiology*
Heart Conduction System / physiology
Heart Valves / pathology,  physiopathology
Humans
Lupus Erythematosus, Systemic / complications*,  immunology,  pathology,  physiopathology
Myocarditis / etiology,  immunology,  physiopathology
Pericarditis / etiology,  immunology,  pathology,  physiopathology
Grant Support
ID/Acronym/Agency:
R0-I AR43727/AR/NIAMS NIH HHS

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