Document Detail

Cardiac involvement in congenital myopathy.
MedLine Citation:
PMID:  4055149     Owner:  NLM     Status:  MEDLINE    
We examined cardiac changes in 8 patients (4 men and 4 women, age 21-43 years) with congenital myopathy proven by skeletal muscle biopsy. Of 8 patients, 4 showed cardiac changes, including 1 with cytoplasmic body myopathy (patient 1), 2 with minimal change myopathy (patients 2 and 3) and 1 with nemaline myopathy (patient 4). Patients 1 and 2 showed left ventricular dilatation with severe global hypokinesis of left ventricular wall. These clinical features were quite similar to those of dilated cardiomyopathy and the patients were in NYHA class 3 or 4. Patient 3 had severe mitral regurgitation with mitral valve prolapse. This patient also had a persistent left superior vena cava and hypoplasia of the aorta, and her cardiac function was in NYHA class 3. Patient 4 showed moderate global left ventricular hypokinesis but the left ventricle was not dilated. This patient also had sino-atrial block and type A Wolff-Parkinson-White syndrome. His cardiac function was NYHA class 1. In conclusion, various types of congenital myopathy are associated with cardiac changes which can result in severe congestive heart failure.
Y Otsuji; M Osame; C Tei; S Minagoe; A Kisanuki; K Arikawa; K Saito; K Nomoto; T Kashima; H Tanaka
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of cardiology     Volume:  9     ISSN:  0167-5273     ISO Abbreviation:  Int. J. Cardiol.     Publication Date:  1985 Nov 
Date Detail:
Created Date:  1985-12-19     Completed Date:  1985-12-19     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  311-22     Citation Subset:  IM    
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MeSH Terms
Arrhythmias, Cardiac / congenital
Cardiac Output
Cardiomyopathies / congenital*,  pathology
Heart Septum / pathology
Heart Valve Diseases / congenital
Heart Ventricles / pathology
Microscopy, Electron
Middle Aged
Muscles / pathology
Muscular Diseases / congenital*,  pathology
Myocardial Contraction

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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