Document Detail

Cardiac involvement in autoimmune myositis and mixed connective tissue disease.
MedLine Citation:
PMID:  16218472     Owner:  NLM     Status:  MEDLINE    
The clinical cardiac manifestations most frequently reported in idiopathic inflammatory myopathies, myositis, are congestive heart failure, conduction abnormalities, that may lead to complete heart block and coronary artery disease. Although clinically overt cardiac involvement is rarely reported in myositis patients, subclinical manifestations are frequently observed and are predominated by conduction abnormalities and arrhythmias detected by ECG. Furthermore, cardiovascular manifestations constitute a major cause of death in myositis, thus cardiac involvement maybe overlooked in these patients. Also children with juvenile dermatomyositis may develop cardiac involvement although the frequency seems to be low. The underlying pathophysiologic mechanisms that may cause cardiac manifestations could involve myocarditis and coronary artery disease as well as involvement of the small vessels of the myocardium. In patients with mixed connective tissue disease (MCTD) clinically significant cardiac involvement is also rare, the most frequently reported manifestations being pericarditis and pulmonary hypertension, the latter often attributable to small vessel disease, and often a prognostic unfavourable manifestation.
I E Lundberg
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Lupus     Volume:  14     ISSN:  0961-2033     ISO Abbreviation:  Lupus     Publication Date:  2005  
Date Detail:
Created Date:  2005-10-12     Completed Date:  2005-12-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9204265     Medline TA:  Lupus     Country:  England    
Other Details:
Languages:  eng     Pagination:  708-12     Citation Subset:  IM    
Rheumatology Unit, Department of Medicine, Karolinska University Hospital, Solna Karolinska Institutet, Stockholm, Sweden.
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MeSH Terms
Autoantibodies / blood
Autoimmune Diseases* / immunology,  pathology,  physiopathology
Diagnosis, Differential
Heart Conduction System / physiopathology
Heart Diseases* / mortality,  pathology,  physiopathology,  therapy
Mixed Connective Tissue Disease* / immunology,  pathology,  physiopathology,  therapy
Myocardium / pathology*
Myositis* / immunology,  pathology,  physiopathology,  therapy
Reg. No./Substance:

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