Document Detail

Cardiac involvement in the Churg-Strauss syndrome.
MedLine Citation:
PMID:  16679097     Owner:  NLM     Status:  MEDLINE    
Churg-Strauss syndrome (CSS) is a rare systemic disease characterized by necrotizing vasculitis and peripheral eosinophilia. Cardiac involvement is considered common and is given a high rank among the causes of morbidity and mortality. The aim of this study was an update on the cardiac manifestations of this syndrome using a noninvasive approach. Sixteen patients with CSS were compared with a gender- and age-matched group of 20 healthy subjects. All patients but 1 were receiving treatment (steroids and/or immunosuppressive drugs). According to the Birmingham vasculitis activity score, 12 patients were in an active phase, and 4 were in drug-induced remission. All subjects underwent M-B-mode echocardiography and Doppler tissue echocardiography. Heart failure, life-threatening arrhythmias, and other prominent manifestations of heart disease were not observed. No differences were found in left ventricular diameter, volume, mass, or ejection fraction. The 2 groups did not differ in right ventricular diameter and pulmonary pressure. Few and nonspecific changes were detected by 2-dimensional echocardiography, including subclinical pericardial effusion and mitral regurgitation, in fewer than half the subjects. Subjects with CSS showed an impairment of ventricular relaxation. Changes were more prominent in the right ventricle. The peak velocity (PV) of early diastolic tricuspid inflow (E) was about 8% less than in controls, and the velocity of late diastolic inflow (A) was 35% greater. The E/A(PV) ratio was, on average, 33% less. In the left ventricle, E(PV) was 11% less and A(PV) 11% greater. The E/A ratio was decreased by 22%. Doppler analysis of tissue kinetics confirmed these indications. In the right ventricle, E(PV) was decreased by 10% and A(PV) was increased by 20% in the patient group. The E/A(PV) ratio was decreased by 29%. In the left ventricle, in which different sites were sampled, the average changes were -15%, +1%, and -23%, respectively. In the left ventricle, the velocity of systolic contraction was also decreased by 12%. Because of the small group size, only some of these differences were statistically significant. In conclusion, these moderate changes, devoid of clinical correlates, contrast with early reports emphasizing cardiac morbidity and poor prognosis in this syndrome.
Giovanna Pelà; Giovanni Tirabassi; Paolo Pattoneri; Laura Pavone; Giovanni Garini; Giacomo Bruschi
Related Documents :
1916997 - Cardiac and aortic effects of angiotensin converting enzyme inhibitors.
2455127 - Regression of left ventricular hypertrophy from systemic hypertension by gallopamil.
24109637 - In vivo patient measurements of bladder elasticity using ultrasound bladder vibrometry ...
2967087 - Patterns of diastolic dysfunction in left ventricular hypertrophy.
18936707 - Hypercapnic acidosis attenuates severe acute bacterial pneumonia-induced lung injury by...
3101387 - Relationship between frequency of ventilation, airways and pulmonary artery pressures, ...
Publication Detail:
Type:  Journal Article     Date:  2006-03-31
Journal Detail:
Title:  The American journal of cardiology     Volume:  97     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  2006 May 
Date Detail:
Created Date:  2006-05-08     Completed Date:  2006-06-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1519-24     Citation Subset:  AIM; IM    
Department of Internal Medicine, Nephrology and Prevention Sciences, University of Parma, Parma, Italy.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Case-Control Studies
Churg-Strauss Syndrome / complications*,  physiopathology,  ultrasonography
Echocardiography, Doppler
Heart Diseases / etiology*,  physiopathology,  ultrasonography
Middle Aged
Statistics, Nonparametric

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Impact of enzyme replacement therapy on cardiac morphology and function and late enhancement in Fabr...
Next Document:  Relation of angiotensin-converting enzyme inhibitor treatment to insulin-like growth factor-1 serum ...