| Cardiac inotropic actions of urocortin in conscious sheep. | |
| | |
MedLine Citation:
|
PMID: 9176276 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Urocortin (Ucn) is a recently isolated peptide related to the corticotropin-releasing factor (CRF) family, which can produce hemodynamic and hormonal actions in conscious rats. This study examined in detail the cardiovascular actions of Ucn and CRF after intravenous injection in chronically instrumented, conscious sheep. Injection of Ucn produced dose-dependent changes in cardiac contractility [rate of increase of aortic flow (dF/dt)], maximum aortic flow (Fmax), mean arterial pressure (MAP), heart rate (HR), cardiac output (CO), and coronary blood flow (CF). Ucn injected at 100 micrograms produced a potent increase in dF/dt, from 909 +/- 44 to a maximum of 1,849 +/- 901.min-1.s-1, and in Fmax, from 25.5 +/- 0.8 to 36.6 +/- 1.4 l/min. Cardiac contractility increased within 30 min of injection and remained significantly elevated for up to 24 h. MAP increased from 78 +/- 2 to 90 +/- 3 mmHg, and HR increased from 73 +/- 4 to 103 +/- 9 beats/min. CO rose from 5.0 +/- 0.1 to 5.8 +/- 0.2 l/min, whereas central venous pressure, total peripheral conductance, and stroke volume were unchanged. All Ucn-induced cardiovascular effects were inhibited by prior treatment with the CRF antagonist alpha-helical CRF-(9-41). Equimolar doses of CRF produced little change in any hemodynamic parameter. Both peptides increased plasma levels of adrenocorticotropin and cortisol, with Ucn having a more potent effect than CRF. We have shown for the first time that Ucn can produce potent and long-lasting actions to elevate cardiac contractility in conscious animals. |
| | |
Authors:
|
D G Parkes; J Vaughan; J Rivier; W Vale; C N May |
Related Documents
:
|
1599626 - The acute dose-related effects of ethanol on right ventricular function in anesthetized... 11788386 - Temperature-dependent postextrasystolic potentiation and ca(2+) recirculation fraction ... 22713146 - A change in paradigm: lowering blood pressure in everyone over a certain age. 11270096 - Effect of stimulating non-myelinated vagal axons on atrio-ventricular conduction and le... 10090346 - A high sucrose, high linoleic acid diet potentiates hypertension in the dahl salt sensi... 3279286 - Angiotensin-converting enzyme inhibitors. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: The American journal of physiology Volume: 272 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1997 May |
Date Detail:
|
Created Date: 1997-06-27 Completed Date: 1997-06-27 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: H2115-22 Citation Subset: IM |
Affiliation:
|
Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Parkville, Victoria, Australia. dparkes@amylin.com |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adrenocorticotropic Hormone
/
blood Animals Corticotropin-Releasing Hormone / pharmacology* Female Hemodynamics / drug effects Hydrocortisone / blood Myocardial Contraction / drug effects* Rats Renin / blood Sheep Urocortins |
| Chemical | |
Reg. No./Substance:
|
0/Urocortins; 50-23-7/Hydrocortisone; 9002-60-2/Adrenocorticotropic Hormone; 9015-71-8/Corticotropin-Releasing Hormone; EC 3.4.23.15/Renin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: In vivo microvascular structural and functional consequences of muscle length changes.
Next Document: Functional implications of myocardial scar structure.