Document Detail

Cardiac injury in patients with COPD presenting with dyspnea: a pilot study.
MedLine Citation:
PMID:  21103406     Owner:  NLM     Status:  MEDLINE    
PURPOSE: The aim of this pilot study was to test the hypothesis that myocardial ischemia complicates the management of some patients with chest-pain-free chronic obstructive pulmonary disease (COPD) exacerbations.
METHODS: In this prospective, observational, cohort study, patients admitted to a 350-bed community teaching hospital, with dyspnea and a primary diagnosis of COPD exacerbation, were followed for enzymatic and electrocardiographic evidence of myocardial ischemia for the first 24 hours of hospital admission.
RESULTS: A total of 114 patients were studied. Overall, four patients had definite myocardial infarctions, one had definite myocardial ischemia and 14 had possible myocardial ischemia. In multiple logistic regression models, age, number of coronary risk factors, and amount of administered albuterol were not associated with myocardial injury.
CONCLUSION: While unrecognized myocardial injury is relatively rare in patients with an exacerbation of COPD, it occurs frequently enough to warrant some caution since beta-agonists are the mainstays of therapy.
Esosa Odigie-Okon; Bryan Jordan; Sylvester Dijeh; Armand Wolff; Razvan Dadu; Priyanka Lall; Stuart Zarich; Yaw Amoateng-Adjepong; Constantine A Manthous
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Publication Detail:
Type:  Journal Article     Date:  2010-11-09
Journal Detail:
Title:  International journal of chronic obstructive pulmonary disease     Volume:  5     ISSN:  1178-2005     ISO Abbreviation:  Int J Chron Obstruct Pulmon Dis     Publication Date:  2010  
Date Detail:
Created Date:  2010-11-24     Completed Date:  2011-02-15     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  101273481     Medline TA:  Int J Chron Obstruct Pulmon Dis     Country:  New Zealand    
Other Details:
Languages:  eng     Pagination:  395-9     Citation Subset:  IM    
Bridgeport Hospital and Yale University School of Medicine, Bridgeport, CT 06610, USA.
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MeSH Terms
Adrenergic beta-Agonists / contraindications
Aged, 80 and over
Biological Markers / blood
Dyspnea / etiology*
Logistic Models
Middle Aged
Myocardial Ischemia / blood,  diagnosis,  etiology*
Odds Ratio
Pilot Projects
Prospective Studies
Pulmonary Disease, Chronic Obstructive / complications*,  drug therapy
Risk Assessment
Risk Factors
Troponin / blood
Reg. No./Substance:
0/Adrenergic beta-Agonists; 0/Biological Markers; 0/Troponin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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