| Cardiac injury in patients with COPD presenting with dyspnea: a pilot study. | |
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MedLine Citation:
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PMID: 21103406 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: The aim of this pilot study was to test the hypothesis that myocardial ischemia complicates the management of some patients with chest-pain-free chronic obstructive pulmonary disease (COPD) exacerbations. METHODS: In this prospective, observational, cohort study, patients admitted to a 350-bed community teaching hospital, with dyspnea and a primary diagnosis of COPD exacerbation, were followed for enzymatic and electrocardiographic evidence of myocardial ischemia for the first 24 hours of hospital admission. RESULTS: A total of 114 patients were studied. Overall, four patients had definite myocardial infarctions, one had definite myocardial ischemia and 14 had possible myocardial ischemia. In multiple logistic regression models, age, number of coronary risk factors, and amount of administered albuterol were not associated with myocardial injury. CONCLUSION: While unrecognized myocardial injury is relatively rare in patients with an exacerbation of COPD, it occurs frequently enough to warrant some caution since beta-agonists are the mainstays of therapy. |
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Authors:
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Esosa Odigie-Okon; Bryan Jordan; Sylvester Dijeh; Armand Wolff; Razvan Dadu; Priyanka Lall; Stuart Zarich; Yaw Amoateng-Adjepong; Constantine A Manthous |
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Publication Detail:
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Type: Journal Article Date: 2010-11-09 |
Journal Detail:
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Title: International journal of chronic obstructive pulmonary disease Volume: 5 ISSN: 1178-2005 ISO Abbreviation: Int J Chron Obstruct Pulmon Dis Publication Date: 2010 |
Date Detail:
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Created Date: 2010-11-24 Completed Date: 2011-02-15 Revised Date: 2013-05-29 |
Medline Journal Info:
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Nlm Unique ID: 101273481 Medline TA: Int J Chron Obstruct Pulmon Dis Country: New Zealand |
Other Details:
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Languages: eng Pagination: 395-9 Citation Subset: IM |
Affiliation:
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Bridgeport Hospital and Yale University School of Medicine, Bridgeport, CT 06610, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic beta-Agonists
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contraindications Aged Aged, 80 and over Biological Markers / blood Connecticut Dyspnea / etiology* Electrocardiography Female Humans Logistic Models Male Middle Aged Myocardial Ischemia / blood, diagnosis, etiology* Odds Ratio Pilot Projects Prospective Studies Pulmonary Disease, Chronic Obstructive / complications*, drug therapy Risk Assessment Risk Factors Troponin / blood |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic beta-Agonists; 0/Biological Markers; 0/Troponin |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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