| Cardiac imaging using Optison. | |
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MedLine Citation:
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PMID: 10997346 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Optison (human albumin microspheres; Mallinckrodt Inc., San Diego, CA) is an injectable suspension contrast agent indicated for use in left-ventricular chamber opacification and endocardial-border delineation. Substantial proportions of patients undergoing echocardiography have inadequate endocardial delineation and, therefore, wall motion (including stress echocardiography) without contrast. The extent of use of Optison for its current indications is likely to vary, and its use will depend upon the patient population and image quality obtained from noncontrast examinations. Early reports exist of its use in as many as 60% of patients undergoing studies in a given echocardiography laboratory. The rate of acceptance for endocardial delineation in stress echocardiography appears to be particularly high, because of the higher proportion of technically challenging studies whether with fundamental or second harmonic imaging. The ability to aid in differentiation of potential artifacts from pathology in the cavity has also been reported. Clinical studies have been conducted or are currently underway to evaluate Optison in the assessment of acute and chronic ischemic coronary artery disease. Studies in patients with unexplained acute chest pain and during exercise and pharmacologic stress have evaluated the ability of Optison to detect perfusion abnormalities as well as wall-motion abnormalities. The rapid evolution of ultrasound imaging modalities such as harmonic Doppler and broad-bond imaging will further enhance Optison's ability to characterize ischemic heart disease patients. |
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Authors:
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L N Clark; H C Dittrich |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: The American journal of cardiology Volume: 86 ISSN: 0002-9149 ISO Abbreviation: Am. J. Cardiol. Publication Date: 2000 Aug |
Date Detail:
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Created Date: 2000-10-02 Completed Date: 2000-10-02 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 0207277 Medline TA: Am J Cardiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 14G-18G Citation Subset: AIM; IM |
Affiliation:
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Molecular Biosystems, Inc., San Diego, California 92121, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Albumins
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diagnostic use* Cardiomyopathies / ultrasonography* Contrast Media* Coronary Circulation Echocardiography / methods* Echocardiography, Doppler, Pulsed Exercise Test Fluorocarbons / diagnostic use* Humans Microspheres Rest |
| Chemical | |
Reg. No./Substance:
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0/Albumins; 0/Contrast Media; 0/FS 069; 0/Fluorocarbons |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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