Document Detail


Cardiac imaging and safety evaluation of BMS747158, a novel PET myocardial perfusion imaging agent, in chronic myocardial compromised rabbits.
MedLine Citation:
PMID:  20339964     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: BMS747158 labeled with (18)F is being developed for PET myocardial perfusion imaging. Imaging studies showed clear detection of necrotic tissue in acute myocardial infarcted (MI) animals and a good safety profile in normal animals. This study evaluated BMS747158 imaging and cardiovascular safety in a rabbit model of chronic MI with cardiac compromise.
METHODS AND RESULTS: Chronic MI rabbits were developed by the left coronary artery ligation followed by 4 weeks recovery. Cardiac PET imaging with BMS747158 (~1.5 mCi, iv) in control rabbits showed clear and uniform myocardial uptake. However, imaging in chronic MI rabbits demonstrated obvious defect area in the left ventricular wall. Before BMS747158 injection, baseline electrocardiogram (ECG) waveforms in lead II configuration were normal with positive QRS complexes in control rabbits. In contrast, MI rabbits exhibited negative QRS complexes with enlarged Q waves and inverted T waves. Baseline values of mean intra-arterial pressure (AP, 61 +/- 6 vs 89 +/- 11 mmHg), systolic AP (79 +/- 11 vs 114 +/- 11 mmHg) and diastolic AP (53 +/- 4 vs 76 +/- 10 mmHg) were lower in MI than in control rabbits. Heart rate (162 +/- 36 vs 159 +/- 8 beat/minute) and QTc interval (corrected by Fridericia method, 288 +/- 17 vs 319 +/- 17 ms) were comparable. BMS747158 administration induced no changes from baseline in any of the measured cardiovascular parameters and ECG waveforms in either control or MI rabbits.
CONCLUSIONS: Cardiac imaging with BMS747158 allows clear detection of chronic MI without producing any cardiovascular alterations in cardiac compromised rabbits.
Authors:
Ming Yu; Jody Bozek; Mary Guaraldi; Mikhail Kagan; Michael Azure; Simon P Robinson
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Publication Detail:
Type:  Journal Article     Date:  2010-03-26
Journal Detail:
Title:  Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology     Volume:  17     ISSN:  1532-6551     ISO Abbreviation:  J Nucl Cardiol     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-20     Completed Date:  2010-11-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9423534     Medline TA:  J Nucl Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  631-6     Citation Subset:  IM    
Affiliation:
Discovery Research, Lantheus Medical Imaging, 331 Treble Cove Rd., N. Billerica, MA 01862, USA. ming.yu@lantheus.com
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MeSH Terms
Descriptor/Qualifier:
Animals
Chronic Disease
Contrast Media
Myocardial Infarction / radionuclide imaging*
Myocardial Perfusion Imaging / adverse effects,  methods*
Positron-Emission Tomography / adverse effects,  methods*
Pyridazines / adverse effects,  diagnostic use*
Rabbits
Radiopharmaceuticals / adverse effects,  diagnostic use
Chemical
Reg. No./Substance:
0/BMS 747158-02; 0/Contrast Media; 0/Pyridazines; 0/Radiopharmaceuticals

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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