Document Detail

Cardiac hypothermia evaluated by ultrastructural studies in man.
MedLine Citation:
PMID:  147968     Owner:  NLM     Status:  MEDLINE    
Transmural left ventricular biopsies from 13 patients undergoing cardiopulmonary bypass were studied. The hypertrophic myocardium was protected by deep hypothermia (15 degrees C.) during ischemic arrest for a maximal period of 96 minutes. Biopsies were taken at the start of bypass, at the end of aortic cross-clamping, and after 20 minutes of reperfusion. The structure of the mitochondria remained normal, whereas cellular alterations in the form of widened intercalated discs, interstitial and intracellular edema, myelin figures, and slight myofibrillar lysis were observed in all stages. As no clear correlation between these structural injuries and aortic cross-clamping time was seen, they are a result of cardiac hypertrophy rather than intraoperative ischemia.
H Engedal; E Skagseth; T S Saetersdal; R Myklebust
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of thoracic and cardiovascular surgery     Volume:  75     ISSN:  0022-5223     ISO Abbreviation:  J. Thorac. Cardiovasc. Surg.     Publication Date:  1978 Apr 
Date Detail:
Created Date:  1978-06-12     Completed Date:  1978-06-12     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0376343     Medline TA:  J Thorac Cardiovasc Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  548-54     Citation Subset:  AIM; IM    
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MeSH Terms
Cardiomegaly / pathology
Cardiopulmonary Bypass*
Evaluation Studies as Topic
Hypothermia, Induced*
Middle Aged
Mitochondria, Heart / ultrastructure
Myocardium / ultrastructure*
Time Factors

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