Document Detail

Cardiac hypertrophy: stressing out the heart.
MedLine Citation:
PMID:  16741569     Owner:  NLM     Status:  MEDLINE    
The question of what differentiates physiological from pathological cardiac hypertrophy remains one of the most clinically relevant questions in basic cardiovascular research. The answer(s) to this question will have far-ranging importance in the fight against hypertrophic heart disease and failure. In this issue of the JCI, Perrino et al. have used a unique model system to mimic the pathophysiologic effects of an intermittent pressure overload on the heart--in effect, to examine the basic issue of what determines an in vivo pathogenic stimulus (see the related article beginning on page 1547). Their findings clearly show that it is the nature of the inciting stimulus, as opposed to chronicity, that establishes the initial pathogenic response and that a distinct disruption of the beta-adrenergic system is centrally involved in the earliest alterations of myocellular physiology. These results suggest both a new paradigm for treatment options in hypertrophic cardiac disease and novel methodologies for further studies.
Jil C Tardiff
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Publication Detail:
Type:  Comment; Journal Article    
Journal Detail:
Title:  The Journal of clinical investigation     Volume:  116     ISSN:  0021-9738     ISO Abbreviation:  J. Clin. Invest.     Publication Date:  2006 Jun 
Date Detail:
Created Date:  2006-06-02     Completed Date:  2006-08-01     Revised Date:  2013-06-07    
Medline Journal Info:
Nlm Unique ID:  7802877     Medline TA:  J Clin Invest     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1467-70     Citation Subset:  AIM; IM    
Albert Einstein College of Medicine, Yeshiva University, Bronx, New York 10461, USA.
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MeSH Terms
Aorta / metabolism,  pathology
Cardiomegaly* / pathology,  physiopathology
Disease Models, Animal
Heart / physiology
Phosphatidylinositol 3-Kinases / metabolism
Physical Conditioning, Animal
Receptors, Adrenergic, beta / metabolism
Stress, Physiological*
Reg. No./Substance:
0/Receptors, Adrenergic, beta; EC 2.7.1.-/Phosphatidylinositol 3-Kinases
Comment On:
J Clin Invest. 2006 Jun;116(6):1547-60   [PMID:  16741575 ]

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