| Cardiac hypertrophy, low blood pressure, and low aldosterone levels in mice devoid of the three circadian PAR bZip transcription factors DBP, HLF, and TEF. | |
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MedLine Citation:
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PMID: 20686175 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The cardiovascular system is under the control of the circadian clock, and disturbed circadian rhythms can induce cardiovascular pathologies. This cyclic regulation is probably brought about by the circadian expression of genes encoding enzymes and regulators involved in cardiovascular functions. We have previously shown that the rhythmic transcription of output genes is, in part, regulated by the clock-controlled PAR bZip transcription factors DBP (albumin D-site binding protein), HLF (hepatic leukemia factor), and TEF (thyrotroph embryonic factor). The simultaneous deletion of all three PAR bZip transcription factors leads to increased morbidity and shortened life span. In the present study, we demonstrate that Dbp/Tef/Hlf triple knockout mice develop cardiac hypertrophy and left ventricular dysfunction associated with a low blood pressure. These dysfunctions are exacerbated by an abnormal response to this low blood pressure characterized by low aldosterone levels. The phenotype of PAR bZip knockout mice highlights the importance of circadian regulators in the modulation of cardiovascular functions. |
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Authors:
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Qing Wang; Marc Maillard; Ueli Schibler; Michel Burnier; Frédéric Gachon |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-08-04 |
Journal Detail:
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Title: American journal of physiology. Regulatory, integrative and comparative physiology Volume: 299 ISSN: 1522-1490 ISO Abbreviation: Am. J. Physiol. Regul. Integr. Comp. Physiol. Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-10-01 Completed Date: 2010-10-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100901230 Medline TA: Am J Physiol Regul Integr Comp Physiol Country: United States |
Other Details:
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Languages: eng Pagination: R1013-9 Citation Subset: IM |
Affiliation:
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Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic beta-Antagonists
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pharmacology Aldosterone / deficiency* Animals Atenolol / pharmacology Basic-Leucine Zipper Transcription Factors / genetics*, physiology Blood Pressure / physiology Cardiomegaly / genetics*, pathology Cardiovascular Physiological Phenomena Circadian Rhythm / genetics*, physiology DNA-Binding Proteins / genetics*, physiology Epithelial Sodium Channel / metabolism Heart Rate / physiology Hypotension / genetics* Kidney / physiology Male Mice Mice, Knockout Phenotype Sympathetic Nervous System / physiology Transcription Factors / genetics*, physiology |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic beta-Antagonists; 0/Basic-Leucine Zipper Transcription Factors; 0/DNA-Binding Proteins; 0/Dbp protein, mouse; 0/Epithelial Sodium Channel; 0/Hlf protein, mouse; 0/Tef protein, mouse; 0/Transcription Factors; 29122-68-7/Atenolol; 52-39-1/Aldosterone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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