Document Detail

Cardiac hypertrophy, low blood pressure, and low aldosterone levels in mice devoid of the three circadian PAR bZip transcription factors DBP, HLF, and TEF.
MedLine Citation:
PMID:  20686175     Owner:  NLM     Status:  MEDLINE    
The cardiovascular system is under the control of the circadian clock, and disturbed circadian rhythms can induce cardiovascular pathologies. This cyclic regulation is probably brought about by the circadian expression of genes encoding enzymes and regulators involved in cardiovascular functions. We have previously shown that the rhythmic transcription of output genes is, in part, regulated by the clock-controlled PAR bZip transcription factors DBP (albumin D-site binding protein), HLF (hepatic leukemia factor), and TEF (thyrotroph embryonic factor). The simultaneous deletion of all three PAR bZip transcription factors leads to increased morbidity and shortened life span. In the present study, we demonstrate that Dbp/Tef/Hlf triple knockout mice develop cardiac hypertrophy and left ventricular dysfunction associated with a low blood pressure. These dysfunctions are exacerbated by an abnormal response to this low blood pressure characterized by low aldosterone levels. The phenotype of PAR bZip knockout mice highlights the importance of circadian regulators in the modulation of cardiovascular functions.
Qing Wang; Marc Maillard; Ueli Schibler; Michel Burnier; Frédéric Gachon
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-08-04
Journal Detail:
Title:  American journal of physiology. Regulatory, integrative and comparative physiology     Volume:  299     ISSN:  1522-1490     ISO Abbreviation:  Am. J. Physiol. Regul. Integr. Comp. Physiol.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-10-01     Completed Date:  2010-10-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100901230     Medline TA:  Am J Physiol Regul Integr Comp Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  R1013-9     Citation Subset:  IM    
Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.
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MeSH Terms
Adrenergic beta-Antagonists / pharmacology
Aldosterone / deficiency*
Atenolol / pharmacology
Basic-Leucine Zipper Transcription Factors / genetics*,  physiology
Blood Pressure / physiology
Cardiomegaly / genetics*,  pathology
Cardiovascular Physiological Phenomena
Circadian Rhythm / genetics*,  physiology
DNA-Binding Proteins / genetics*,  physiology
Epithelial Sodium Channel / metabolism
Heart Rate / physiology
Hypotension / genetics*
Kidney / physiology
Mice, Knockout
Sympathetic Nervous System / physiology
Transcription Factors / genetics*,  physiology
Reg. No./Substance:
0/Adrenergic beta-Antagonists; 0/Basic-Leucine Zipper Transcription Factors; 0/DNA-Binding Proteins; 0/Dbp protein, mouse; 0/Epithelial Sodium Channel; 0/Hlf protein, mouse; 0/Tef protein, mouse; 0/Transcription Factors; 29122-68-7/Atenolol; 52-39-1/Aldosterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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