| Cardiac hypertrophy induced by thyroid hormone is independent of loading conditions and beta adrenoceptor blockade. | |
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MedLine Citation:
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PMID: 2537405 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study was designed to determine whether thyroid hormone (T4) produces cardiac hypertrophy and alters ventricular function by direct effects on the heart or by alterations in adrenergic stimulation or changes in the peripheral circulation. Rats were treated with captopril (4 mg/ml of drinking water), propranolol (0.5 mg/ml of drinking water), hydralazine (80 mg/l of drinking water) or the combination of captopril and propranolol with and without T4 (15 micrograms/100 g b.w. i.p.). After 10 days, T4 increased (P less than .01) heart rate, left ventricular (LV) dP/dt and LV weight/body weight, but did not alter LV systolic pressure (SP) or enddiastolic pressure (EDP). Compared to treatment with T4 alone, captopril plus T4 decreased LV SP (P less than .05) and LV EDP (P less than .01); however, heart rate, LV dP/dt and LV weight/body weight were unchanged. Treatment with T4 plus propranolol decreased heart rate and LV EDP (P less than .05) compared to T4 alone; however, LV SP, LV dP/dt and LV weight/body weight were unchanged (P greater than .05). Hydralazine did not alter (P greater than .05) heart rate, LV SP, LV EDP or prevent the development of increased LV weight/body weight when given with T4; however, LV dP/dt was slightly decreased (P less than .05). Treatment with the combination of captopril and propranolol did not alter (P greater than .05) heart rate, LV SP, LV EDP or LV dP/dt and also failed to prevent the development of increased LV weight/body weight and LV dP/dt when given with T4.(ABSTRACT TRUNCATED AT 250 WORDS) |
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Authors:
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J B Bedotto; R G Gay; S D Graham; E Morkin; S Goldman |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The Journal of pharmacology and experimental therapeutics Volume: 248 ISSN: 0022-3565 ISO Abbreviation: J. Pharmacol. Exp. Ther. Publication Date: 1989 Feb |
Date Detail:
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Created Date: 1989-04-03 Completed Date: 1989-04-03 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 0376362 Medline TA: J Pharmacol Exp Ther Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 632-6 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, Veterans Administration Medical Center, Tucson, Arizona. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Captopril / pharmacology Cardiomegaly / chemically induced* Heart / drug effects, physiopathology Hydralazine / pharmacology Isoenzymes / analysis Male Myosins / analysis Propranolol / pharmacology Rats Rats, Inbred Strains Receptors, Adrenergic, beta / drug effects* Thyroid Hormones / pharmacology* |
| Grant Support | |
ID/Acronym/Agency:
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HL-20984/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Isoenzymes; 0/Receptors, Adrenergic, beta; 0/Thyroid Hormones; 525-66-6/Propranolol; 62571-86-2/Captopril; 86-54-4/Hydralazine; EC 3.6.4.1/Myosins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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