| Cardiac and hemodynamic profile of the new cardiotonic agent, DPI 201-106, in the conscious dog. | |
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MedLine Citation:
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PMID: 2767134 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The cardiac and hemodynamic effects of increasing doses (0.1-3 mg/kg i.v.) of the novel cardiotonic agent, DPI 201-106 (DPI), were investigated over a 60 min period in conscious dogs chronically instrumented for the measurement of arterial pressure, heart rate, left ventricular pressure (LVP), LV (+) dP/dtmax and cardiac output. LV (+) dP/dtmax, cardiac output and stroke volume were significantly increased by DPI whereas the total peripheral resistance was significantly decreased. These effects were dose-dependent in intensity and in duration. The mean arterial pressure and heart rate remained unaffected, except by the 3 mg/kg dose, which increased them slightly. Autonomic blockade with hexamethonium, atropine and propranolol did not alter the positive inotropic properties of DPI but unmasked its intrinsic bradycardic effect. At equipotent positive inotropic doses, DPI (0.3 mg/kg), milrinone (40 micrograms/kg) and dobutamine (5 micrograms/kg per min) induced similar increases in cardiac output and similar decreases in total peripheral resistance, but only dobutamine and milrinone accelerated the heart rate, whereas ouabain (17.5 micrograms/kg) induced a strong rise in the total peripheral resistance and markedly lowered the heart rate and cardiac output. After coadministration of DPI and ouabain, LV (+) dP/dtmax was further increased whereas the ouabain-induced bradycardia, the rise in the total peripheral resistance and the decrease in cardiac output were reinforced, halved and unaltered, respectively. We conclude that (a) DPI exhibits potent and direct positive inotropic properties, associated with a peripheral vasodilating action, and almost no positive chronotropic effects, and (b) coadministration of DPI and ouabain results in synergistic positive inotropic effects. |
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Authors:
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J L Gerard; A Berdeaux; J F Giudicelli |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: European journal of pharmacology Volume: 165 ISSN: 0014-2999 ISO Abbreviation: Eur. J. Pharmacol. Publication Date: 1989 Jun |
Date Detail:
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Created Date: 1989-10-05 Completed Date: 1989-10-05 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 1254354 Medline TA: Eur J Pharmacol Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 39-49 Citation Subset: IM |
Affiliation:
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Département de Pharmacologie, Faculté de Médecine Paris-Sud, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Autonomic Nervous System / drug effects Cardiotonic Agents* Dobutamine / pharmacology Dogs Drug Interactions Female Heart / drug effects* Hemodynamics / drug effects* Male Milrinone Myocardial Contraction / drug effects Ouabain / pharmacology Piperazines / pharmacology* Pyridones / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Cardiotonic Agents; 0/Piperazines; 0/Pyridones; 34368-04-2/Dobutamine; 630-60-4/Ouabain; 78415-72-2/Milrinone; 97730-95-5/DPI 201-106 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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