Document Detail

Cardiac glycogen repletion after exercise: influence of synthase and glucose 6-phosphate.
MedLine Citation:
PMID:  402347     Owner:  NLM     Status:  MEDLINE    
Previous studies have shown that cardiac glycogen content is replenished to supranormal levels after exercise. To better understand this phenomenon glycogen synthase (GS) %I activity as well as glucose 6-phosphate (G-6-P) and glycogen (G) concentrations were measured in hearts from normal and alloxan diabetic rats killed at various time intervals before or after a treadmill run to exhaustion. In normal animals at exhaustion G was reduced but GS %I and G-6-P were elevated. During 2-8 h of recovery G was elevated, %I depressed, and G-6-P unchanged when compared to their preexercise values. By contrast, diabetic hearts that had elevated G and low %I were characterized by abnormally high G-6-P concentrations. At exhaustion in these hearts %I increased significantly in response to a decrease in G. These findings suggest that glycogen repletion occurs in normal heart as a result of the combined increases in GS %I and G-6-P levels present at the cessation of work. In both normal and diabetic hearts there exists an inverse relationship between G content and GS %I activity.
R K Conlee; C M Tipton
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of applied physiology: respiratory, environmental and exercise physiology     Volume:  42     ISSN:  0161-7567     ISO Abbreviation:  J Appl Physiol Respir Environ Exerc Physiol     Publication Date:  1977 Feb 
Date Detail:
Created Date:  1977-04-28     Completed Date:  1977-04-28     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  7801242     Medline TA:  J Appl Physiol Respir Environ Exerc Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  240-4     Citation Subset:  IM; S    
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MeSH Terms
Blood Glucose / metabolism
Diabetes Mellitus, Experimental / metabolism*
Glucosephosphates / metabolism*
Glycogen / metabolism*
Glycogen Synthase / metabolism*
Myocardium / enzymology,  metabolism*
Physical Exertion*
Reg. No./Substance:
0/Blood Glucose; 0/Glucosephosphates; 9005-79-2/Glycogen; EC Synthase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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