| Cardiac functions in children with coeliac disease during follow-up: insights from tissue Doppler imaging. | |
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MedLine Citation:
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PMID: 18165163 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The identification of a coeliac disease in patients with idiopathic dilated cardiomyopathy raises critical questions on the relationship between the two entities. But cardiac functions have not been studied in patients with coeliac disease. The present study was undertaken to assess cardiac functions by Tissue Doppler Echocardiography in patient with coeliac disease. METHODS: We studied 45 clinically stable patients; twenty-five patients with positive serum IgA Antiendomysial Antibody levels (Group 1), twenty patients with negative serum IgA Antiendomysial Antibody levels (Group 2) at the time of echocardiographic study. Control group consisted of 30 healthy children free of any disease. RESULTS: Myocardial systolic wave velocity of the mitral annulus was significantly lower (p<0.001), myocardial precontraction and contraction time were slightly longer in Group 2 when compared control group (p=0.015, p=0.044, respectively). There was a negative correlation between the serum IgA Antiendomysial Antibody levels titers and myocardial systolic wave levels of all patients included in the study (r = -0.633; p<0.001). A myocardial systolic wave velocity of <8.9 cm/s had a 92% sensitivity and 80% specificity in predicting serum IgA Antiendomysial Antibody levels positive patients. CONCLUSIONS: We detected subclinical systolic dysfunction of the left ventricle in children with coeliac disease in whom serum IgA Antiendomysial Antibody reactivity is prominent. Tissue Doppler echocardiography provides a quantifiable indicator useful for cardiac monitoring of disease during follow up. |
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Authors:
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Tugcin B Polat; Nafiye Urganci; Yalim Yalcin; Cenap Zeybek; Celal Akdeniz; Abdullah Erdem; Elnur Imanov; Ahmet Celebi |
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Publication Detail:
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Type: Comparative Study; Journal Article Date: 2007-12-31 |
Journal Detail:
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Title: Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver Volume: 40 ISSN: 1590-8658 ISO Abbreviation: Dig Liver Dis Publication Date: 2008 Mar |
Date Detail:
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Created Date: 2008-02-11 Completed Date: 2008-06-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100958385 Medline TA: Dig Liver Dis Country: Netherlands |
Other Details:
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Languages: eng Pagination: 182-7 Citation Subset: IM |
Affiliation:
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Department of Pediatric Cardiology, Dr. Siyami Ersek Thoracic and Cardiovascular Surgery Hospital, 5 Gazeteciler sitesi A1 Blok 3 nolu villa, Akatlar-Istanbul, Istanbul, Turkey. tugcin75@mynet.com |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Antibodies, Anti-Idiotypic / blood Atrial Function / physiology* Cardiomyopathy, Dilated / etiology, physiopathology*, ultrasonography Celiac Disease / complications, immunology, physiopathology* Child Child, Preschool Echocardiography, Doppler / methods* Female Follow-Up Studies Heart Atria / physiopathology*, ultrasonography Heart Ventricles / physiopathology*, ultrasonography Humans Immunoglobulin A / immunology Male Myocardial Contraction / physiology Prognosis Time Factors Ventricular Function / physiology* |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Anti-Idiotypic; 0/Immunoglobulin A |
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