Document Detail

Cardiac functions in children with coeliac disease during follow-up: insights from tissue Doppler imaging.
MedLine Citation:
PMID:  18165163     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The identification of a coeliac disease in patients with idiopathic dilated cardiomyopathy raises critical questions on the relationship between the two entities. But cardiac functions have not been studied in patients with coeliac disease. The present study was undertaken to assess cardiac functions by Tissue Doppler Echocardiography in patient with coeliac disease. METHODS: We studied 45 clinically stable patients; twenty-five patients with positive serum IgA Antiendomysial Antibody levels (Group 1), twenty patients with negative serum IgA Antiendomysial Antibody levels (Group 2) at the time of echocardiographic study. Control group consisted of 30 healthy children free of any disease. RESULTS: Myocardial systolic wave velocity of the mitral annulus was significantly lower (p<0.001), myocardial precontraction and contraction time were slightly longer in Group 2 when compared control group (p=0.015, p=0.044, respectively). There was a negative correlation between the serum IgA Antiendomysial Antibody levels titers and myocardial systolic wave levels of all patients included in the study (r = -0.633; p<0.001). A myocardial systolic wave velocity of <8.9 cm/s had a 92% sensitivity and 80% specificity in predicting serum IgA Antiendomysial Antibody levels positive patients. CONCLUSIONS: We detected subclinical systolic dysfunction of the left ventricle in children with coeliac disease in whom serum IgA Antiendomysial Antibody reactivity is prominent. Tissue Doppler echocardiography provides a quantifiable indicator useful for cardiac monitoring of disease during follow up.
Tugcin B Polat; Nafiye Urganci; Yalim Yalcin; Cenap Zeybek; Celal Akdeniz; Abdullah Erdem; Elnur Imanov; Ahmet Celebi
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2007-12-31
Journal Detail:
Title:  Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver     Volume:  40     ISSN:  1590-8658     ISO Abbreviation:  Dig Liver Dis     Publication Date:  2008 Mar 
Date Detail:
Created Date:  2008-02-11     Completed Date:  2008-06-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100958385     Medline TA:  Dig Liver Dis     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  182-7     Citation Subset:  IM    
Department of Pediatric Cardiology, Dr. Siyami Ersek Thoracic and Cardiovascular Surgery Hospital, 5 Gazeteciler sitesi A1 Blok 3 nolu villa, Akatlar-Istanbul, Istanbul, Turkey.
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MeSH Terms
Antibodies, Anti-Idiotypic / blood
Atrial Function / physiology*
Cardiomyopathy, Dilated / etiology,  physiopathology*,  ultrasonography
Celiac Disease / complications,  immunology,  physiopathology*
Child, Preschool
Echocardiography, Doppler / methods*
Follow-Up Studies
Heart Atria / physiopathology*,  ultrasonography
Heart Ventricles / physiopathology*,  ultrasonography
Immunoglobulin A / immunology
Myocardial Contraction / physiology
Time Factors
Ventricular Function / physiology*
Reg. No./Substance:
0/Antibodies, Anti-Idiotypic; 0/Immunoglobulin A

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