Document Detail

Cardiac function in ten-year old twins following different fetal therapies for twin-twin transfusion syndrome.
MedLine Citation:
PMID:  24347245     Owner:  NLM     Status:  Publisher    
OBJECTIVES: Compare cardiac function at ten years in three groups of monochorionic twin pairs (MCDA): uncomplicated MCDA (n = 6), Twin-Twin Transfusion Syndrome (TTTS) managed by amnioreduction (TTTS-amnio, n = 9) or laser photocoagulation (TTTS-laser, n = 10).and dichorionic (DCDA, n = 6) controls.
METHODS: Echocardiograms optimising apical 4-chamber and short axis left ventricular views were stored for off-line speckle-tracking analysis, blinded to twin type. Myocardial long axis shortening (S') and lengthening (E' and A') velocities were measured using pulsed Doppler at the cardiac base. M-mode measurements of fractional shortening (short axis) and maximal displacement of the atrioventricular annulus (4-chamber) were recorded. Syngo Vector Velocity Imaging software tracked left ventricular myocardial motion off-line to produce free wall Strain, Strain Rate and Rotation. Inter-twin pair and group differences were investigated using ANOVA.
RESULTS: Cardiac measurements lay within normal ranges for 10 year olds. No significant within twin-pair and inter-group differences were found in current size, heart rates, Strain or Strain Rate. Compared to DCDA controls, TTTS showed lower cardiac rotation (TTTS-laser, p < 0.001 and TTTS-amnio, p = 0.054) with significant inter-twin pair reduction in ex-Recipient, TTTS-amnio (p = 0.006) and larger MCDA twins (p = 0.027) compared to their co-twins. A similar pattern was seen in left ventricular early relaxation velocities (MVE') in all monochorionic groups only achieving significance in TTTS-amnio (p = 0.037). Intra-pair differences in rotation and MVE' were significantly different following treatment at Quintero stages 3 or 4.
CONCLUSIONS: Within twin-pair patterns of left ventricular rotation and diastolic function differ at 10 years in ex-Recipients of TTTS-amnio compared with TTTS-laser and controls.
Helena M Gardiner; Hikoro Matsui; Michael Roughton; Stephen E Greenwald; Anke Diemert; Myles Jo Taylor; Kurt Hecher
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-12-18
Journal Detail:
Title:  Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology     Volume:  -     ISSN:  1469-0705     ISO Abbreviation:  Ultrasound Obstet Gynecol     Publication Date:  2013 Dec 
Date Detail:
Created Date:  2013-12-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9108340     Medline TA:  Ultrasound Obstet Gynecol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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This article is protected by copyright. All rights reserved.
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