Document Detail

Cardiac function in Vietnamese patients with different dengue severity grades.
MedLine Citation:
PMID:  21946658     Owner:  NLM     Status:  Publisher    
OBJECTIVE:: Dengue continues to cause significant global morbidity and mortality. Severe disease is characterized by cardiovascular compromise from capillary leakage. Cardiac involvement in dengue has also been reported but has not been adequately studied. SETTING:: Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam. DESIGN:: Seventy-nine patients aged 8-6 yrs with different dengue severity grades were studied using echocardiography including tissue Doppler imaging. The patients were split into severity grades: dengue, dengue with warning signs, and severe dengue. Changes in cardiac functional parameters and hemodynamic indices were monitored over the hospital stay. MEASUREMENTS AND MAIN RESULTS:: Patients with severe dengue had worse cardiac function compared with dengue in the form of left ventricular systolic dysfunction with increased left myocardial performance index (0.58 [0.26-0.80] vs. 0.38 [0.22-0.70], p = .006). Septal myocardial systolic velocities were reduced (6.4 [4.8-10] vs. 8.1 [6-13] cm/s, p = .01) as well as right ventricular systolic (11.4 [7.5-17] vs. 13.5 [10-17] cm/s, p = .016) and diastolic velocities (13 [8-23] vs. 17 [12-25] cm/s, p = .0026). In the severe group, these parameters improved from hospital admission to discharge; septal myocardial systolic velocities to 8.8 (7-11) cm/s (p = .002), right ventricular myocardial systolic velocities to 15.0 (11.8-23) cm/s, (p = .003), and diastolic velocity to 21 (11-25) cm/s (p = .002). Patients with cardiac impairment were more likely to have significant pleural effusions. CONCLUSIONS:: Patients with severe dengue have evidence of systolic and diastolic cardiac impairment with septal and right ventricular wall being predominantly affected.
Sophie Yacoub; Anna Griffiths; Tran Thi Hong Chau; Cameron P Simmons; Bridget Wills; Tran Tinh Hien; Michael Henein; Jeremy Farrar
Related Documents :
17629178 - Retrospective study of pulmonary hypertensive patients: is right ventricular myocardial...
14715188 - Tissue doppler imaging predicts recovery of left ventricular function after recanalizat...
7930238 - Increased left ventricular diastolic chamber stiffness immediately after coronary arter...
2642998 - Assessment of diastolic function of the heart: background and current applications of d...
10626748 - Thrombotic risk associated with the use of iodinated contrast media in interventional c...
23945038 - High anxiety in clinically healthy patients and increased qt dispersion: a meta-analysis.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-9-22
Journal Detail:
Title:  Critical care medicine     Volume:  -     ISSN:  1530-0293     ISO Abbreviation:  -     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-9-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0355501     Medline TA:  Crit Care Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
From the Department of Infection and Immunity (SY), Imperial College, London, UK; the Department of Echocardiography (AG), Guys and St. Thomas' NHS Trust, London, UK; the Hospital for Tropical Diseases (TTHC), Ho Chi Minh City, Vietnam; Oxford University Clinical Research Unit (CPS, BW, TTH, JF), Wellcome Trust Major Overseas Programme, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam; and the Department of Public Health and Clinical Medicine (MH), Umea University Sweden, Umea, Sweden, and Canterbury Christ Church University, Canterbury, UK.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Hypercapnic acidosis attenuates reperfusion injury in isolated and perfused rat lungs.
Next Document:  Prevention of ventilator-associated pneumonia or ventilator-associated complications: A worthy, yet ...