Document Detail

Cardiac function during mental stress: cholinergic modulation with pyridostigmine in healthy subjects.
MedLine Citation:
PMID:  12627998     Owner:  NLM     Status:  MEDLINE    
Mentally or emotionally stressful situations occur throughout our lives and cause physiological haemodynamic responses. In patients with coronary artery disease, such events can also induce myocardial ischaemia and ventricular arrhythmias, increasing mortality rates. The purpose of the present study was to determine the acute effects of the oral administration of pyridostigmine, a reversible cholinesterase inhibitor and thus an indirect cholinomimetic drug, on echocardiographic variables during mental stress in healthy subjects. A total of 18 healthy young volunteers were subjected to mental stress tests (mental arithmetic and the Stroop colour-word test) 2 h after the oral administration of either placebo or pyridostigmine bromide (45 mg), using a balanced-randomized, double-blind, crossover protocol. During mental stress, heart rate (pyridostigmine, 64+/-1 beats/min; placebo, 70+/-1 beats/min; P =0.0003) and diastolic blood pressure (pyridostigmine, 66+/-2 mmHg; placebo, 79+/-3 mmHg; P =0.01) were lower in the pyridostigmine group, but systolic pressure was not (pyridostigmine, 124+/-3 mmHg; placebo, 123+/-3 mmHg; P =0.40). There were no detectable abnormalities in the left ventricular wall motion score during mental stress, but left ventricular outflow tract mean velocity (pyridostigmine, 0.68+/-0.02 m/s; placebo, 0.64+/-0.02 m/s; P <0.05) and mitral inflow velocity deceleration (placebo, 4.05+/-0.18 m/s(2); pyridostigmine, 4.41+/-0.16 m/s(2); P <0.05) were higher in the pyridostigmine group. In conclusion, cholinergic stimulation with pyridostigmine seems to increase left ventricular diastolic function during mental stress in healthy subjects.
Isis Délio Sant'anna; Eduardo Branco de Sousa; Alvaro Villela de Moraes; Débora Lopes Loures; Evandro Tinoco Mesquita; Antonio Claudio Lucas da Nóbrega
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Clinical science (London, England : 1979)     Volume:  105     ISSN:  0143-5221     ISO Abbreviation:  Clin. Sci.     Publication Date:  2003 Aug 
Date Detail:
Created Date:  2003-07-22     Completed Date:  2003-09-16     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7905731     Medline TA:  Clin Sci (Lond)     Country:  England    
Other Details:
Languages:  eng     Pagination:  161-5     Citation Subset:  IM    
Department of Physiology and Pharmacology and Post-Graduate Program in Cardiology, Instituto Biomédico, Universidade Federal Fluminense, Rua Prof. Hernani Pires de Melo 101, Niterói, RJ 24210-130, Brazil.
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MeSH Terms
Blood Flow Velocity / drug effects
Blood Pressure / drug effects
Cholinesterase Inhibitors / pharmacology*
Cross-Over Studies
Double-Blind Method
Heart Rate / drug effects
Hemodynamics / drug effects
Pyridostigmine Bromide / pharmacology*
Stress, Psychological / physiopathology*
Ventricular Function, Left / drug effects*
Reg. No./Substance:
0/Cholinesterase Inhibitors; 101-26-8/Pyridostigmine Bromide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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