Document Detail


Cardiac function and antiepileptic drug treatment in the elderly: a comparison between lamotrigine and sustained-release carbamazepine.
MedLine Citation:
PMID:  19400874     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: To investigate the comparative effects of carbamazepine (CBZ) and lamotrigine (LTG) on electrocardiography (ECG) parameters in elderly patients with newly diagnosed epilepsy.
METHODS: The study was conducted in the Norwegian subcohort (n = 108) of an international randomized double-blind 40-week trial, which compared the efficacy and tolerability of LTG and sustained-release CBZ in patients aged 65 and older with newly diagnosed epilepsy. Target maintenance doses were 400 mg/day for CBZ and 100 mg/day for LTG, with adjustments based on clinical response. Patients with significant unpaced atrioventricular (AV) conduction defect were excluded. Resting 12-lead ECG recordings were made under standardized conditions at pretreatment (baseline) and at the 40-week study visit (treatment visit). Changes in QRS interval (primary endpoint), heart rate (HR), PQ, and QTc (HR-corrected QT) intervals were assessed and compared between groups.
RESULTS: Of the 108 patients randomized, 33 discontinued prematurely because of adverse events (n = 24, none of which was cardiac) or other reasons (n = 9), and 15 were nonevaluable due to incomplete ECG data. None of the assessed ECG parameters differed significantly between groups at baseline. No significant ECG changes were recorded between baseline and treatment visit for QRS duration and QTc intervals, whereas HR fell and PQ intervals increased slightly on both treatments. However, there were no differences between groups in changes from baseline to treatment visit. There were no significant relationships between individual ECG changes and serum drug concentrations, except for QTc intervals, which decreased slightly with increasing CBZ concentrations. The proportion of patients with ECG parameters outside the normal range at treatment visit was similar to that recorded at baseline.
DISCUSSION: Clinically significant ECG changes are not common during treatment with CBZ or LTG in elderly patients with no preexisting significant AV conduction defects.
Authors:
Erik Saetre; Mikael Abdelnoor; Jan Peder Amlie; Morten Tossebro; Emilio Perucca; Erik Taubøll; Ole Gunnar Anfinsen; Jouko Isojärvi; Leif Gjerstad
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Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2009-03-23
Journal Detail:
Title:  Epilepsia     Volume:  50     ISSN:  1528-1167     ISO Abbreviation:  Epilepsia     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-08-17     Completed Date:  2009-08-28     Revised Date:  2013-08-21    
Medline Journal Info:
Nlm Unique ID:  2983306R     Medline TA:  Epilepsia     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1841-9     Citation Subset:  IM    
Affiliation:
Epilepsy Unit, Department of Adult Habilitation, Ullevål University Hospital, Oslo, Norway. erik.saetre@ulleval.no
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Anticonvulsants / pharmacology,  therapeutic use
Carbamazepine / pharmacology*,  therapeutic use*
Cardiovascular System / drug effects*
Cohort Studies
Double-Blind Method
Drug Delivery Systems
Electrocardiography
Epilepsy / drug therapy*,  physiopathology*
Female
Geriatric Assessment
Heart Rate / drug effects
Humans
Male
Norway
Statistics, Nonparametric
Triazines / pharmacology*,  therapeutic use*
Chemical
Reg. No./Substance:
0/Anticonvulsants; 0/Triazines; 298-46-4/Carbamazepine; U3H27498KS/lamotrigine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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