Document Detail


Cardiac function after alcohol ingestion in patients with ischemic heart disease and cardiomyopathy: a controlled study.
MedLine Citation:
PMID:  3358819     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Thirty male patients with ischemic heart disease and cardiomyopathy entered a controlled study of the acute effects of alcohol on cardiac function evaluated by right heart catheterization. Twenty patients, nine with angina pectoris and 11 with congestive heart failure, were studied during alcohol intoxication, and ten patients, five with angina pectoris and five with heart failure, served as a control group. The mean serum ethanol concentration in the alcohol group was 93 mg/100 ml (S.D. 17). The systemic arterial blood pressure was reduced by 6% in the alcohol group, P less than 0.05 compared with the control group. No significant changes occurred in the central venous pressure, the pulmonary artery pressure, the pulmonary capillary wedge pressure, or in cardiac output, stroke volume and total peripheral resistance. Alcohol intake in moderate doses has no measurable effect on pulmonary blood pressures or cardiac output in patients with ischemic heart disease and cardiomyopathy. Such an effect may, however, be masked by a reduction of afterload.
Authors:
H Kelbaek; L Heslet; K Skagen; O Munck; N J Christensen; J Godtfredsen
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Alcohol and alcoholism (Oxford, Oxfordshire)     Volume:  23     ISSN:  0735-0414     ISO Abbreviation:  Alcohol Alcohol.     Publication Date:  1988  
Date Detail:
Created Date:  1988-06-09     Completed Date:  1988-06-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8310684     Medline TA:  Alcohol Alcohol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  17-21     Citation Subset:  IM    
Affiliation:
Department of Clinical Physiology and Nuclear Medicine, Herlev Hospital, University of Copenhagen, Denmark.
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MeSH Terms
Descriptor/Qualifier:
Aged
Alcoholic Intoxication / complications
Cardiac Output / drug effects
Ethanol / pharmacology*
Heart / drug effects*
Heart Diseases / complications,  physiopathology*
Heart Rate / drug effects
Humans
Male
Middle Aged
Stroke Volume / drug effects
Chemical
Reg. No./Substance:
64-17-5/Ethanol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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