Document Detail

Cardiac function of an acute ischemic heart failure model produced by microsphere injection into the left coronary artery. Pressure-volume relationship as determined by a conductance catheter.
MedLine Citation:
PMID:  8589467     Owner:  NLM     Status:  MEDLINE    
The authors produced an acute canine heart failure model by injecting microspheres (phi 15.5 +/- 0.1 mm, 5 x 10(5)) into the left coronary artery, and characterized the model in terms of the pressure-volume relationship obtained by the conductance catheter method. Cardiodynamics of the microsphere injection group (M group: n = 10) and control group (C group: n = 12) were studied with 1) heart rate, 2) aortic pressure, 3) cardiac output (CO), 4) maximal ventricular elastance, 5) effective arterial elastance/maximal ventricular elastance, and 6) external work/pressure-volume area efficiency. With microsphere injection, CO and external work/pressure-volume area efficiency significantly decreased. With administration of dobutamine (5 mg/kg/min), CO and maximal ventricular elastance recovered to normal and aortic pressure became higher than normal. These changes in heart rate, aortic pressure, CO, maximal ventricular elastance, and external work/pressure-volume area efficiency in the M group were comparable in percentage to those in the C groups. Cardiodynamics of this heart failure model generally were stable for 3 hrs after microsphere injection. The authors concluded that this model would be an excellent acute heart failure model for investigating hemodynamic effects of circulatory assist devices.
H Kuroda; H Suga
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  ASAIO journal (American Society for Artificial Internal Organs : 1992)     Volume:  41     ISSN:  1058-2916     ISO Abbreviation:  ASAIO J.     Publication Date:    1995 Oct-Dec
Date Detail:
Created Date:  1996-03-27     Completed Date:  1996-03-27     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9204109     Medline TA:  ASAIO J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  855-62     Citation Subset:  IM    
Department of Surgery, Shinshu University School of Medicine, Matsumoto, Japan.
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MeSH Terms
Blood Pressure / physiology
Cardiac Output / physiology
Coronary Vessels / physiopathology*
Disease Models, Animal
Heart / physiopathology*
Heart Catheterization
Heart Conduction System / physiology
Heart Failure / chemically induced,  physiopathology
Heart Rate / physiology
Myocardial Ischemia / chemically induced,  physiopathology*
Ventricular Function, Left

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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