Document Detail


Cardiac findings in Behçet's patients.
MedLine Citation:
PMID:  20534096     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Behçet's disease is a chronic multi-system inflammatory disorder and the severity and clinical manifestations of Behçet's patients may show geographic variation. We aimed to detect the cardiac findings in 30 Behçet's patients and compare them with the normal population (n = 29). We used color-doppler echocardiography and transesophageal echocardiography in combination. We calculated manually QT intervals and QT dispersion (QTd) from twelve-lead ECG recordings. There was no E/A inversion and coronary ischemia in all patients or control group. The E velocity difference between groups was not significant. The mean A velocity was significantly lower in Behçet's patients than normal group. The mean DT was 154.4 +/- 5.8 msec in Behçet's patients and 122.59 +/- 0.96 msec in control group (P < 0.0001). The mean IVRT was 75.66 +/- 1.36 msec in Behçet's patients and 69.1 +/- 0.55 msec in control group (P < 0.0001). There was no QTc time difference between the Behçet's patients and the control group. The mean QT dispersion (QTd) interval was 45.46 +/- 2.65 msec in Behçet's patients and 31.83 +/- 1.23 msec in control group (P < 0.0001). Atrial septal aneurysm, mitral valve prolapse and insufficiency, tricuspid valve insufficieny, and pulmonary hypertension frequencies in Behçet's patients were significantly higher than in the control group. We concluded that Behçet's cardiac involvement may effect cardiac structure and cause diastolic dysfunction, electrical instability and structural abnormalities. We also concluded that cardiac involvement in Behçet's disease may be specific for this geographic area.
Authors:
Gulumser Heper; Mualla Polat; Ertan Yetkin; Kubilay Senen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of dermatology     Volume:  49     ISSN:  1365-4632     ISO Abbreviation:  Int. J. Dermatol.     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-06-10     Completed Date:  2010-09-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0243704     Medline TA:  Int J Dermatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  574-8     Citation Subset:  IM    
Affiliation:
Department of Cardiology, AIB University, Bolu, Turkey. heperg@hotmail.com
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MeSH Terms
Descriptor/Qualifier:
Adult
Behcet Syndrome / physiopathology,  ultrasonography*
Echocardiography, Doppler, Color
Echocardiography, Transesophageal
Female
Heart Aneurysm / physiopathology,  ultrasonography*
Humans
Hypertension, Pulmonary / physiopathology,  ultrasonography*
Male
Middle Aged
Mitral Valve Insufficiency / physiopathology,  ultrasonography*
Mitral Valve Prolapse / physiopathology,  ultrasonography*
Tricuspid Valve Insufficiency / physiopathology,  ultrasonography*
Young Adult

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