Document Detail

Cardiac fibroblast in development and wound healing.
MedLine Citation:
PMID:  24625635     Owner:  NLM     Status:  Publisher    
Cardiac fibroblasts are the most abundant cell type in the mammalian heart and comprise approximately two-thirds of the total number of cardiac cell types. During development, epicardial cells undergo epithelial-mesenchymal-transition to generate cardiac fibroblasts that subsequently migrate into the developing myocardium to become resident cardiac fibroblasts. Fibroblasts form a structural scaffold for the attachment of cardiac cell types during development, express growth factors and cytokines and regulate proliferation of embryonic cardiomyocytes. In post natal life, cardiac fibroblasts play a critical role in orchestrating an injury response. Fibroblast activation and proliferation early after cardiac injury are critical for maintaining cardiac integrity and function, while the persistence of fibroblasts long after injury leads to chronic scarring and adverse ventricular remodeling. In this review, we discuss the physiologic function of the fibroblast during cardiac development and wound healing, molecular mediators of activation that could be possible targets for drug development for fibrosis and finally the use of reprogramming technologies for reversing scar. This article is part of a Special Issue entitled 'Cardiac Fibroblast Review'.
Arjun Deb; Eric Ubil
Related Documents :
22973235 - Cardiac electrophysiology in mice: a matter of size.
23046685 - Double inter-atrial septum: a rare cause of cardioembolic stroke.
12040345 - Relationship between coronary angioplasty laboratory volume and outcomes after hospital...
25000555 - High sensitivity of late gadolinium enhancement for predicting microscopic myocardial s...
15853565 - Hmg coa reductase inhibitors (statins): use in stroke prevention and outcome after stroke.
9596425 - Response times and outcomes for cardiac arrests in las vegas casinos.
Publication Detail:
Type:  REVIEW     Date:  2014-3-10
Journal Detail:
Title:  Journal of molecular and cellular cardiology     Volume:  -     ISSN:  1095-8584     ISO Abbreviation:  J. Mol. Cell. Cardiol.     Publication Date:  2014 Mar 
Date Detail:
Created Date:  2014-3-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0262322     Medline TA:  J Mol Cell Cardiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2014. Published by Elsevier Ltd.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Yellow Fever outbreaks in unvaccinated populations, Brazil, 2008-2009.
Next Document:  Depression and anxiety in prostate cancer: a systematic review and meta-analysis of prevalence rates...