Document Detail

Cardiac exercise hemodynamics late after partial left ventriculectomy.
MedLine Citation:
PMID:  11082387     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Although some patients report favorable activity levels late after partial left ventriculectomy (PLV), their exercise physiology has not been well described. METHODS AND RESULTS: We performed upright bicycle hemodynamics in 10 patients (9 men) aged 56+/-12 years at 1.7 years after PLV. Ejection fraction was 25+/-4%. Patients biked 10+/-7 minutes. With exercise, the mean pulmonary arterial pressure rose from 36+/-12 to 52+/-10 mm Hg (P:=0.0003). The mean pulmonary capillary wedge pressure rose from 25+/-14 to 36+/-9 mm Hg (P:=0.0566), and the cardiac index rose from 2.2+/-0.5 to 3.8+/-1.6 L. min(-1). m(-2) (P:=0.0077). The mixed venous oxygenation with exercise declined from 44+/-9% to 24+/-17% (P:=0. 0220), and the pulmonary vascular resistance increased from 2.0+/-0. 9 to 2.3+/-1.1 Wood units (P:=0.5566). CONCLUSIONS: In late follow-up after PLV with exercise, the cardiac index is significantly augmented. However, there are further rises in pulmonary artery and pulmonary capillary wedge pressures, suggesting abnormal compliance, with marked decline in mixed venous oxygenation. Elucidating late physiology after PLV may help pave the way for future innovative heart failure surgeries.
K B James; G Haas; S R Lutton; D Prior; K Wolski; T Buda; P M McCarthy
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Circulation     Volume:  102     ISSN:  1524-4539     ISO Abbreviation:  Circulation     Publication Date:  2000 Nov 
Date Detail:
Created Date:  2000-11-22     Completed Date:  2000-12-28     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0147763     Medline TA:  Circulation     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  III200-3     Citation Subset:  IM    
Department of Cardiology, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA.
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MeSH Terms
Blood Gas Analysis
Blood Pressure
Exercise Test
Heart Function Tests
Heart Ventricles / physiopathology*,  surgery*,  ultrasonography
Middle Aged
Pulmonary Artery / physiopathology
Pulmonary Wedge Pressure
Vascular Resistance

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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