Document Detail


Cardiac electrophysiological effects of prostacyclin analogues, 7-oxo-PGI2 and iloprost.
MedLine Citation:
PMID:  2449187     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of stable prostacyclin (PGI2) analogues, Iloprost (Schering) and 7-oxo-PGI2 (Chinoin) on transmembrane action potential (AP) of guinea pig left auricle and right papillary muscle were studied. 7-oxo-PGI2 (10(-7)-10(-5) M) without causing any significant effect on AP and on the maximum rate of rise (Vmax) of AP accelerated only the repolarization phase at high concentration in both preparations. Iloprost (1.4 x 10(-7)-1.4 x 10(-5) M) had a slight hyperpolarizing effect and it decreased the duration of atrial AP. In ventricular preparation Iloprost depressed the amplitude of the obershoot (OS), shortened the duration of AP and at high concentration (1.4 x 10(-5) M) caused a slight, significant increase in Vmax. Iloprost had no effect on slow AP induced by adrenaline in K+ depolarized ventricular fibers. Some electrophysiological effects of Iloprost can be explained by changing K+ permeability.
Authors:
V Kecskemeti
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Biomedica biochimica acta     Volume:  46     ISSN:  0232-766X     ISO Abbreviation:  Biomed. Biochim. Acta     Publication Date:  1987  
Date Detail:
Created Date:  1988-03-15     Completed Date:  1988-03-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8304435     Medline TA:  Biomed Biochim Acta     Country:  GERMANY, EAST    
Other Details:
Languages:  eng     Pagination:  S460-4     Citation Subset:  IM    
Affiliation:
Department of Pharmacology, Semmelweis University of Medicine, Budapest, Hungary.
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MeSH Terms
Descriptor/Qualifier:
Action Potentials / drug effects
Animals
Electrophysiology
Epoprostenol / pharmacology*
Guinea Pigs
Heart / drug effects*,  physiology
Iloprost
Potassium / metabolism
Chemical
Reg. No./Substance:
35121-78-9/Epoprostenol; 7440-09-7/Potassium; 78919-13-8/Iloprost; 79821-50-4/7-oxoprostaglandin I2

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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