| Cardiac electrophysiological actions and interactions of ethanol, cocaine, and the metabolite ethylcocaine. | |
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MedLine Citation:
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PMID: 9817212 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The influence of ethanol on the actions of cocaine and ethylcocaine on rat sinoatrial preparations was studied. Ethanol did not modify the depressant effect of cocaine or ethylcocaine on sinoatrial rate (SR) in preparations with spontaneous activity. Cocaine produced sinoatrial block only in the presence of ethanol, and the latter accentuated the sinoatrial block produced by ethylcocaine. Ethanol did not modify the depressant effect of cocaine or ethylcocaine on membrane potentials of atrial fibers in preparations driven at a constant rate. In conclusion, ethanol, in a concentration that did not by itself affect SR or produce sinoatrial block, accentuated the effects of cocaine and ethylcocaine on sinoatrial conduction, without modifying the effects on SR. It is proposed that the accentuation of the block was the consequence of the combination of a depressant action on the fast sodium system and a deterioration of the cell-to-cell coupling. |
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Authors:
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A K Jain; R G Carpentier |
Publication Detail:
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Type: Comparative Study; In Vitro; Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of electrocardiology Volume: 31 ISSN: 0022-0736 ISO Abbreviation: J Electrocardiol Publication Date: 1998 Oct |
Date Detail:
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Created Date: 1999-01-21 Completed Date: 1999-01-21 Revised Date: 2009-11-11 |
Medline Journal Info:
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Nlm Unique ID: 0153605 Medline TA: J Electrocardiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 293-302 Citation Subset: IM |
Affiliation:
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Department of Physiology and Biophysics, College of Medicine, Howard University, Washington, DC 20059, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Action Potentials
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drug effects Animals Cocaine / analogs & derivatives*, pharmacology* Drug Interactions Electrophysiology Ethanol / pharmacology* Male Microelectrodes Rats Rats, Sprague-Dawley Sinoatrial Block / chemically induced*, physiopathology Sinoatrial Node / drug effects*, physiopathology |
| Grant Support | |
ID/Acronym/Agency:
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S06GM8016/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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50-36-2/Cocaine; 529-38-4/cocaethylene; 64-17-5/Ethanol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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