Document Detail


Cardiac electromechanical mapping in analyzing the mechanism of left ventricular remodeling immediately after percutaneous transluminal septal ablation in patients with hypertrophic obstructive cardiomyopathy.
MedLine Citation:
PMID:  16336814     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Effect of percutaneous transluminal septal ablation (PTSA) with ethanol injection on electromechanical remodeling of left ventricule still remains unknown. This study was conducted to assess the potential significance of cardiac electromechanical mapping (CEMM) in analyzing the left ventricular remodeling before and immediately after percutaneous transseptal myocardial ablation (PTSMA) in patients with hypertrophic obstructive cardiomyopathy (HOCM). METHODS: Eight patients with drug-refractory HOCM and 6 patients with hypertrophic cardiopathy (HM) without increased left ventricular outtract gradien (LVOTG) were enrolled into the present study. CEMM was undergone in patients with HOCM before and immediately after PTSA procedure, and in patients with HM. RESULTS: PTSA was successful in all patients with HOCM, LVOTG significantly decreased from (62.87 +/- 21.16) mmHg to (12.73 +/- 3.05) mmHg immediately after ablation procedure. Value of UVP in septal-base segment in HM group was higher than that in HOCM group [(22.79 +/- 2.34) mV vs (18.54 +/- 1.76) mV]. In patients with HOCM, lateral-middle and -base segments had lowest value of UVP [(15.93 +/- 1.11) mV and (15.83 +/- 1.07) mV] before PTSA. Value of UVP at posterior-middle segment decreased from (23.58 +/- 2.21) mV pre-PTSA to (18.89 +/- 1.91) mV post-procedure, PTSA led to significant increase of UVP at lateral-middle segment. Septal region in patients with HM and septal-middle, septal-base, posterior-base segments in HOCM had lower value of local linear shortening (LLS) among all patients in both HOCM and HM groups. PTSA resulted in significant reduction of LLS in anterior region and at septal-apex segment. Anterior-base and septal-middle segments in patients with HM had lowest value of local active time (LAT), and significantly differentiated from that in patients with HOCM [(-8.57 +/- 0.68) ms vs (-18.61 +/- 1.02) ms, (-6.75 +/- 0.37)ms vs (-21.90 +/- 0.96) ms, respectively]. LAT at septal-middle and -base segments in patients with HOCM was decreased significantly [(-21.90 +/- 0.96) ms vs (-13.80 +/- 1.04) ms, P < 0.002; and (-15.20 +/- 1.06) ms vs (-6.33 +/- 0.52) ms, respectively] immediately after PTSA. CONCLUSIONS: Posterior-lateral and anterior region probably played important roles in electromechanical remodeling. Significant electromechanical remodeling disassociation (uncoupling) was detected in most left ventricular regions, which would be important in differentiating of HOCM from HM, and in predicting the prognosis in patients with HOCM after PTSA procedure.
Authors:
Shao-liang Chen; Jun Huang; Fei Ye; Shou-jie Shan; Jun-jie Zhang; Bao-xiang Duan; Yun-dai Chen
Related Documents :
17629614 - Multiple sclerosis and capgras' syndrome.
8289084 - Cardiovascular autonomic dysfunction in multiple sclerosis is likely related to brainst...
21078694 - Primary progressive versus relapsing-onset multiple sclerosis: presence and prognostic ...
18693994 - Acceptance of home telemanagement is high in patients with multiple sclerosis.
3499074 - Sucralfate suspension versus titrated antacid for the prevention of acute stress-relate...
3207074 - Immunoelectrophoretic tailing albumin phenomenon. associations with clinical characteri...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Chinese medical journal     Volume:  118     ISSN:  0366-6999     ISO Abbreviation:  Chin. Med. J.     Publication Date:  2005 Nov 
Date Detail:
Created Date:  2005-12-12     Completed Date:  2005-12-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7513795     Medline TA:  Chin Med J (Engl)     Country:  China    
Other Details:
Languages:  eng     Pagination:  1779-85     Citation Subset:  IM    
Affiliation:
Cardiological Division, Nanjing First Hospital of Nanjing Medical University, Nanjing 210006, China. chmengx@126.com
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Body Surface Potential Mapping*
Cardiomyopathy, Hypertrophic / physiopathology,  therapy*
Ethanol / therapeutic use*
Heart Septum / drug effects*
Humans
Ventricular Remodeling / physiology*
Chemical
Reg. No./Substance:
64-17-5/Ethanol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Recurrent atrial tachycardia and atrial fibrillation after circumferential pulmonary vein ablation: ...
Next Document:  Impact of pathogen burden on in-stent restenosis in patients after coronary stent implantation.