Document Detail


Cardiac effects of L/N-type Ca2+ channel blocker cilnidipine in anesthetized dogs.
MedLine Citation:
PMID:  17445796     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cardiac effects of L/N-type Ca2+ channel blocker cilnidipine were assessed using the halothane-anesthetized canine model. Cilnidipine (1 and 3 microg/kg, i.v.) lowered the mean blood pressure by -5 and -14 mm Hg, respectively, without affecting the heart rate or maximum upstroke velocity of left ventricular pressure. Isoproterenol or acetylcholine was intravenously injected to directly or indirectly induce the positive chronotropic responses, respectively. Cilnidipine hardly affected the isoproterenol-induced cardiac responses, but it attenuated the acetylcholine-induced reflex tachycardia to 63-78% of the pre-drug control level. These results suggest that clinically relevant doses of cilnidipine can directly attenuate the sympathetic tone.
Authors:
Akira Takahara; Hiroshi Iwasaki; Yuji Nakamura; Atsushi Sugiyama
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-03-24
Journal Detail:
Title:  European journal of pharmacology     Volume:  565     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  2007 Jun 
Date Detail:
Created Date:  2007-05-28     Completed Date:  2007-07-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  166-70     Citation Subset:  IM    
Affiliation:
Department of Pharmacology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Chuo, Yamanashi 409-3898, Japan.
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MeSH Terms
Descriptor/Qualifier:
Anesthesia
Animals
Blood Pressure / drug effects
Calcium Channel Blockers / pharmacology*
Calcium Channels, L-Type / drug effects*
Calcium Channels, N-Type / drug effects*
Dihydropyridines / pharmacology*
Dogs
Female
Heart / drug effects*
Heart Rate / drug effects
Male
Nifedipine / pharmacology
Sympatholytics / pharmacology
Chemical
Reg. No./Substance:
0/Calcium Channel Blockers; 0/Calcium Channels, L-Type; 0/Calcium Channels, N-Type; 0/Dihydropyridines; 0/Sympatholytics; 132203-70-4/cilnidipine; 21829-25-4/Nifedipine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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