| Cardiac effects of a selective rho-associated kinase inhibitor, Y-27632, assessed in canine isolated, blood-perfused heart preparations. | |
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MedLine Citation:
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PMID: 11949893 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Chronotropic, inotropic and coronary effects of Y-27632 ((+)-(R)-trans-4-(1-aminoethyl)-N-(4-pyridyl) cyclohexanecarboxamide dihydrochloride, monohydrate), a specific inhibitor of Rho-associated coiled-coil forming protein serine/threonine kinase (ROCK), were assessed using canine isolated, blood-perfused heart preparations. Y-27632 slightly enhanced sinoatrial automaticity and significantly increased coronary blood flow, while it decreased ventricular contraction. The concentrations of Y-27632 needed to cause the currently observed changes were similar to those inhibiting ROCK in a previous in vitro study. These results suggest that the constitutional ROCK in the heart mainly regulates the ventricular contractility and coronary vascular tone rather than the sinoatrial automaticity. |
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Authors:
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Atsushi Sugiyama; Yutaka Yatomi; Akira Takahara; Yoshioki Satoh; Keitaro Hashimoto |
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Publication Detail:
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Type: In Vitro; Journal Article |
Journal Detail:
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Title: Japanese journal of pharmacology Volume: 88 ISSN: 0021-5198 ISO Abbreviation: Jpn. J. Pharmacol. Publication Date: 2002 Mar |
Date Detail:
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Created Date: 2002-04-12 Completed Date: 2002-10-04 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 2983305R Medline TA: Jpn J Pharmacol Country: Japan |
Other Details:
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Languages: eng Pagination: 359-61 Citation Subset: IM |
Affiliation:
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Department of Pharmacology, Yamanashi Medical University, Nakakoma-gun, Japan. atsushis@res.yamanashi-med.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Amides
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pharmacology* Animals Coronary Circulation / drug effects Cross Circulation Dogs Enzyme Inhibitors / pharmacology* Female Heart / drug effects* Heart Rate / drug effects Intracellular Signaling Peptides and Proteins Male Myocardial Contraction / drug effects Perfusion Protein-Serine-Threonine Kinases / antagonists & inhibitors* Pyridines / pharmacology* Sinoatrial Node / drug effects Vasodilation / drug effects rho-Associated Kinases |
| Chemical | |
Reg. No./Substance:
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0/Amides; 0/Enzyme Inhibitors; 0/Intracellular Signaling Peptides and Proteins; 0/Pyridines; 138381-45-0/Y 27632; EC 2.7.11.1/Protein-Serine-Threonine Kinases; EC 2.7.11.1/rho-Associated Kinases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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