Document Detail


Cardiac effects of the extract and active components of Radix stephaniae tetrandrae. I. Electrically-induced intracellular calcium transient and protein release during the calcium paradox.
MedLine Citation:
PMID:  11432451     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The present study was designed to compare the cardiac actions of the extract and individual components, tetrandrine (Tet) and fangchinoline (Fan), of Radix stephaniae tetrandrae (RST). We measured the electrically induced [Ca2+]i transient in single rat ventricular myocytes and protein release following perfusion with a Ca2+ free solution (the Ca2+ paradox) from the isolated perfused rat heart, both of which are known to relate to Ca2+ influx. We found that Tet inhibited both electrically induced [Ca2+]i transient and protein release during the Ca2+ paradox, while Fan had no significant effects. The RST extract containing 9% Tet and 6% Fan by weight also affected the [Ca2+]i transient, and was only slightly, though significantly, less effective/potent than Tet alone. On the other hand, RST extract had a significantly greater inhibitory effect on protein release during the Ca2+ paradox than Tet alone. The observations suggest that the RST extract, which contains a mixture of components, may have more potent effects in the heart than its main active component.
Authors:
S Wu; X C Yu; J Shan; T M Wong; C F Chen; K T Pang
Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Life sciences     Volume:  68     ISSN:  0024-3205     ISO Abbreviation:  Life Sci.     Publication Date:  2001 May 
Date Detail:
Created Date:  2001-07-02     Completed Date:  2001-07-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375521     Medline TA:  Life Sci     Country:  England    
Other Details:
Languages:  eng     Pagination:  2853-61     Citation Subset:  IM    
Affiliation:
Department of Physiology, Faculty of Medicine, The University of Hong Kong, Hong Kong.
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MeSH Terms
Descriptor/Qualifier:
Alkaloids / pharmacology*
Animals
Benzylisoquinolines*
Calcium / metabolism*
Calcium Channel Blockers / pharmacology*
Dose-Response Relationship, Drug
Drug Interactions
Drugs, Chinese Herbal / pharmacology*
Electric Stimulation
Heart Ventricles / drug effects*,  metabolism
Male
Myocardium / cytology,  metabolism
Proteins / metabolism*
Rats
Rats, Sprague-Dawley
Chemical
Reg. No./Substance:
0/Alkaloids; 0/Benzylisoquinolines; 0/Calcium Channel Blockers; 0/Drugs, Chinese Herbal; 0/Proteins; 33889-68-8/fangchinoline; 518-34-3/tetrandrine; 7440-70-2/Calcium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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