| Cardiac effects of adding electrolytes and oxygen to iohexol in a dog model of contrast media-induced ventricular fibrillation. | |
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MedLine Citation:
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PMID: 7833168 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We investigated whether addition of a balanced electrolyte supplement and oxygen to the nonionic contrast medium iohexol reduces the risk of ventricular fibrillation (VF), and studied regional electrophysiology prior to the VF event. Twenty ml of each test solution were infused at a rate of 0.5 ml/s into the left anterior descending coronary artery (LAD) in 8 anesthetized dogs. LAD was externally occluded during infusion, to simulate a wedged catheter situation. ECG, hemodynamics, regional epicardial monophasic action potential duration (MAPD) and ventricular activation times (VAT) were calculated. All infusions with iohexol caused VF within 27 s. Five of 12 infusions with iohexol + 30 mmol NaCl, 3 of 11 infusions with iohexol+electrolytes (IPE) NaCl, KCl, CaCl2 and MgCl2) and 4 of 11 infusions with IPE with oxygen addition (IPE+O2) caused VF after 45 s. Iohexol did not change MAPD prior to the VF event. Iohexol + 30 mmol NaCl and the IPE solutions lengthened MAPD initially, but at the time of the VF event MAPD were normalized or shortened. We conclude that electrolyte supplement to iohexol may prevent VF, probably by lengthening MAPD. |
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Authors:
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E A Jacobsen; H K Pedersen; N E Kløw; H Refsum |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Acta radiologica (Stockholm, Sweden : 1987) Volume: 36 ISSN: 0284-1851 ISO Abbreviation: Acta Radiol Publication Date: 1995 Jan |
Date Detail:
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Created Date: 1995-02-24 Completed Date: 1995-02-24 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8706123 Medline TA: Acta Radiol Country: DENMARK |
Other Details:
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Languages: eng Pagination: 47-53 Citation Subset: IM |
Affiliation:
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Department of Radiology, University Hospital, Tromsø, Norway. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Action Potentials
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drug effects Animals Dogs Electrocardiography Electrolytes / pharmacology* Female Heart / drug effects* Iohexol / toxicity* Male Osmolar Concentration Oxygen / pharmacology* Risk Factors Time Factors Ventricular Fibrillation / chemically induced*, prevention & control |
| Chemical | |
Reg. No./Substance:
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0/Electrolytes; 66108-95-0/Iohexol; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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