| Cardiac effects of HDL and its components on diabetic cardiomyopathy. | |
| | |
MedLine Citation:
|
PMID: 22236025 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Diabetic cardiopathy includes a specific cardiomyopathy, which occurs in the absence of coronary heart disease and hypertension under diabetes mellitus. Hyperglycemia, hyperinsulinemia, and hyperlipidemia, characteristic metabolic disturbances evident in diabetes mellitus, all three lead to a specific altered cardiac structure and function. Recently, it has been demonstrated that altered HDL, be it low HDL or dysfunctional HDL is not only a consequence of diabetes mellitus, but can also contribute to the development of diabetes mellitus, and therefore also of diabetic cardiomyopathy. This review summarizes how HDL can indirectly affect diabetic cardiomyopathy via their influence on the metabolic triggers hyperglycemia, hyperinsulinemia, and hyperlipidemia, and how they can directly influence the cardiac cellular consequences, typical for diabetic cardiomyopathy, including inflammation, oxidative stress, apoptosis, fibrosis, Ca2+ handling, glucose homeostasis, and endothelial dysfunction. |
| | |
Authors:
|
Frank Spillmann; Sophie Van Linthout; Carsten Tschöpe |
Related Documents
:
|
9214735 - Sustained harvest of camptothecin from the leaves of camptotheca acuminata. 22025375 - Impact of body mass index and waist circumference on the long-term risk of diabetes mel... 878915 - A family with dominantly inherited mild juvenile diabetes. 21851295 - Lipotoxicity and cardiac dysfunction in mammals and drosophila. 17454835 - Insulin resistance after cardiopulmonary bypass in the elderly patient. 18380275 - Skeletal muscle metabolic dysfunction in obesity and metabolic syndrome. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-1-11 |
Journal Detail:
|
Title: Endocrine, metabolic & immune disorders drug targets Volume: - ISSN: 2212-3873 ISO Abbreviation: Endocr Metab Immune Disord Drug Targets Publication Date: 2012 Jan |
Date Detail:
|
Created Date: 2012-1-12 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101269157 Medline TA: Endocr Metab Immune Disord Drug Targets Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Department of Cardiology & Pneumology Charité - University Medicine Berlin Campus Benjamin Franklin Hindenburgdamm 30 12200 Berlin. carsten.tschoepe@charite.de. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Bone marrow microenvironment: a newly recognized target for diabetes-induced cellular damage.
Next Document: Molecular mechanisms of diabetes and atherosclerosis: Role of adiponectin.